Sermorelin Acetate is a growth peptides research compound currently in stock directly from a verified Chinese manufacturer. Every batch is HPLC-verified and shipped with a Certificate of Analysis (COA). Sourcing is direct — no intermediaries. Minimum order value is $600 USD. International shipping available.
Sermorelin is a synthetic 29-amino acid peptide corresponding to the biologically active N-terminal fragment of endogenous human growth hormone-releasing hormone (GHRH), specifically GHRH(1–29). The full-length native GHRH is 44 amino acids, but the first 29 residues contain the complete receptor-binding domain required for GHRH receptor (GHRHR) activation — a finding established by systematic truncation studies in pituitary cell models. Sermorelin was the first synthetic GHRH analogue to complete clinical development for paediatric GH deficiency — later withdrawn for commercial rather than safety reasons — providing a body of human pharmacokinetic and pharmacodynamic data uncommon for research peptides.
The key pharmacokinetic limitation of sermorelin relative to its structural successors is its short plasma half-life of approximately 10–12 minutes, attributable to rapid cleavage at the His²-Ala³ bond by dipeptidyl aminopeptidase IV (DPP-IV). This sensitivity makes it a useful negative pharmacological control in DPP-IV inhibition studies, and underlies the development of the four-substitution analogue CJC-1295 Without DAC (Modified GRF 1-29), which confers DPP-IV resistance while retaining the same receptor pharmacology. In research comparing GHRH analogue half-life and GH pulse kinetics, sermorelin serves as the short-acting reference compound.
PeptidesFromChina.co supplies sermorelin as the acetate salt in lyophilized form at ≥98% purity, verified by HPLC and confirmed by mass spectrometry. Certificates of Analysis per batch. Wholesale quantities available on request. For laboratory research use only.
| Chemical Class | GHRH Analogue — N-terminal Fragment |
|---|---|
| Also Known As | GHRH(1-29), GRF 1-29, Somatocrinin(1-29) |
| CAS Number | 86168-78-7 |
| Molecular Formula | C₁₄₉H₂₄₆N₄₄O₄₂S |
| Molecular Weight | 3357.9 Da (free base) |
| Sequence Length | 29 amino acids (native GHRH N-terminal sequence) |
| Receptor Target | GHRHR (Growth Hormone-Releasing Hormone Receptor) |
| DPP-IV Sensitivity | High — cleavage at His²-Ala³ bond (t½ ~10–12 min) |
| Storage | -20°C lyophilized; 4°C reconstituted (up to 14 days) |
| Name | Strength | Pack Size | Purity | Availability | Price (USD) |
|---|---|---|---|---|---|
| Sermorelin Acetate | 5 mg | 10 vials | ≥98% | In Stock | $82.00 |
| Sermorelin Acetate | 10 mg | 10 vials | ≥98% | In Stock | $157.00 |
Testing method: HPLC / LC-MS. Every batch is tested before shipment. Purity ≥99% confirmed per batch.
Certificate of Analysis (COA) is included with every order. Documentation covers purity, molecular weight, and batch identification.
Sermorelin acts at the pituitary GHRHR to stimulate cAMP production and GH release from somatotroph cells. Its 29-residue sequence reproduces the full GHRHR-binding activity of native GHRH(1-44). Primary rat anterior pituitary cell cultures and GHRHR-transfected cell lines are standard in vitro assay formats for characterising sermorelin potency, with cAMP accumulation and GH release (by radioimmunoassay or ELISA) as readouts. In vivo rat and primate studies document dose-dependent GH peak responses with a rapid onset and short duration consistent with its plasma half-life.
Sermorelin's high DPP-IV sensitivity — it is cleaved within minutes in plasma — makes it the standard short-acting reference compound in GHRH analogue pharmacokinetic studies. Comparative experiments measuring GH pulse area under the curve (AUC) after equimolar doses of sermorelin versus CJC-1295 Without DAC (Modified GRF 1-29) demonstrate the functional consequence of DPP-IV resistance: larger and more sustained GH peaks with the modified analogue. These studies use DPP-IV activity assays (with synthetic fluorescent substrates) and plasma sermorelin ELISA to quantify in vivo degradation kinetics.
Sermorelin's clinical development programme for GH deficiency generated substantial translational data in both rodent models (dwarf rats, hypophysectomised rats) and human clinical trials. In these models, sermorelin administration partially restored linear growth, lean body mass, and IGF-1 levels in GH-deficient animals — providing preclinical benchmarks against which newer GHRH analogues are compared. The compound is used as the reference GHRH agonist in preclinical growth model studies where historical datasets from the clinical programme provide cross-species translation context.
Endogenous GHRH is a key mediator of the dominant slow-wave sleep (SWS) GH pulse, released from the hypothalamus during the transition into deep sleep. Sermorelin administration in sleep research protocols in rodents and humans augments SWS GH pulses without disrupting sleep architecture, consistent with its physiological role. EEG/polysomnography studies in aged animal models use sermorelin to test whether age-associated decline in nocturnal GH pulses can be restored by exogenous GHRHR stimulation — a model relevant to the biology of somatopause.
Both are 29-amino acid GHRH analogues that bind and activate the GHRHR. Sermorelin is the native GHRH(1-29) sequence with no modifications, making it rapidly inactivated by DPP-IV (half-life ~10–12 minutes). CJC-1295 Without DAC (Modified GRF 1-29) contains four amino acid substitutions that confer DPP-IV resistance, extending half-life to ~25–30 minutes and producing a larger GH pulse AUC per dose. Researchers choose sermorelin when a native-sequence reference compound is required, or CJC-1295 Without DAC for more sustained GH stimulation per injection.
Sermorelin acetate is the standard pharmaceutical and research grade form. The acetate counterion improves the peptide's solubility and lyophilization stability compared to the free base form. In aqueous reconstitution, the acetate salt dissolves readily in sterile water or PBS. For cell culture work, the acetate concentration at research doses (nM–μM range) is negligible relative to standard culture medium buffering capacity and does not affect assay results.
PeptidesFromChina.co verifies sermorelin purity by RP-HPLC (≥98%) and confirms identity by ESI-MS matching the expected molecular mass. Certificates of Analysis from the synthesis facility are provided with each batch. For studies requiring additional characterisation (amino acid analysis, endotoxin testing), contact us to discuss available analytical packages.
Yes. Sermorelin acetate is available through PeptidesFromChina.co on a B2B wholesale basis with volume-tiered pricing. Contact us via the Request page or Contact form for pricing and minimum order quantities after account verification.
For laboratory research use only. Not for human or veterinary use. PeptidesFromChina.co is a B2B wholesale supplier operating under strict research-use-only terms. All products are sold exclusively for in vitro and preclinical research purposes.