TB-500 is a healing & repair research compound available to order directly from a verified Chinese manufacturer. Every batch is tested by the manufacturer for purity and concentration as part of routine quality control. Sourcing is direct — no intermediaries. Minimum order value is $600 USD. International shipping available.
TB-500 (Thymosin Beta-4 Acetate) is a synthetic 43-amino acid polypeptide corresponding to the full sequence of Thymosin Beta-4, a naturally occurring protein found in virtually all mammalian cells and the most abundant G-actin-sequestering protein in eukaryotic cells. Unlike locally-acting peptides, TB-500's primary research interest lies in its systemic distribution and its role in actin regulation — the structural process fundamental to cell migration, differentiation, and tissue remodeling.
Preclinical research in rodent and rodent-based cardiac models has examined TB-500 in contexts including wound closure, ischemia-reperfusion injury recovery, and musculoskeletal injury models. Its mechanism of interest centers on G-actin sequestration and promotion of cellular migration, which distinguishes it from BPC-157's more localized gastroprotective and repair profile.
PeptidesFromChina.co supplies TB-500 as a lyophilized powder in 5mg and 10mg vials, synthesized to 99%+ purity verified by HPLC and Mass Spectrometry. Every batch is tested by the manufacturer for purity and concentration as part of routine quality control. All products are intended for laboratory research use only and are not for human consumption.
| Chemical Class | Synthetic polypeptide (actin-binding) |
|---|---|
| Synonyms | Thymosin Beta-4 Acetate, Tβ4, TB4 |
| Sequence | Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-Thr-Glu-Thr-Gln-Glu-Lys-Asn-Pro-Leu-Pro-Ser-Lys-Glu-Thr-Ile-Glu-Gln-Glu-Lys-Gln-Ala-Gly-Glu-Ser |
| Amino Acids | 43 |
| Molecular Formula | C₂₁₂H₃₅₀N₅₆O₇₈S |
| Molecular Weight | ~4963 Da |
| CAS Number | 77591-33-4 |
| PubChem CID | 16132341 |
| Research Areas | Systemic tissue recovery, wound healing, cardiac protection, cellular migration, inflammation |
| Form | Lyophilized powder |
| Storage | −20°C long-term; 2-8°C aqueous up to 2 weeks |
| Name | Strength | Pack Size | Purity | Availability | Price (USD) |
|---|---|---|---|---|---|
| TB-500 (Thymosin Beta-4 Acetate) | 2 mg | 10 vials | ≥98% | Out of Stock | $50.00 |
| TB-500 (Thymosin Beta-4 Acetate) | 5 mg | 10 vials | ≥98% | Out of Stock | $88.00 |
| TB-500 (Thymosin Beta-4 Acetate) | 10 mg | 10 vials | ≥98% | Out of Stock | $173.00 |
Testing method: HPLC / LC-MS (["HPLC","LC-MS","Endotoxins","Heavy Metals","Sterility","Water Content","Visible Particulates","Assay","Impurities"]). Every batch is tested before shipment. Purity ≥99% confirmed per batch.
Available documentation: Manufacturer COA · Simple COA. Where provided, these documents reflect the manufacturer's batch testing for this compound.
TB-500 has been studied in multiple wound healing models, including full-thickness dermal wound studies in rodents. Research has focused on the compound's apparent acceleration of re-epithelialization and angiogenesis through G-actin sequestration and cellular migration promotion — key processes in tissue remodeling.
Cardiac research represents one of the most studied areas of Thymosin Beta-4 activity. Rodent studies in ischemia-reperfusion injury models have examined its apparent role in cardiomyocyte survival and neovascularization following myocardial infarction, with proposed mechanisms involving actin cytoskeletal regulation and anti-apoptotic signaling.
Rodent models of muscle injury have examined systemic TB-500 administration in contexts of muscle fiber repair and post-injury fibrosis reduction. Research interest in this area is driven by the compound's systemic distribution profile, which differentiates it from locally-acting repair peptides like BPC-157.
The relationship between TB-500 and Thymosin Beta-4 involves a well-known market distinction. Thymosin Beta-4 is a naturally occurring 43-amino acid protein present in virtually all mammalian cells. Certain regulatory bodies — including WADA — reference "TB-500" in the context of a shorter heptapeptide fragment derived from Thymosin Beta-4 (amino acids 17–23, Ac-LKKTETQ). However, the broader research supply market has consistently used "TB-500" to refer to the complete 43-amino acid Thymosin Beta-4 sequence, and this remains the dominant convention. Our TB-500 is the full 43-amino acid Thymosin Beta-4 Acetate — the complete polypeptide. We also supply the actin-binding region fragment (residues 17-24) as a separate SKU — TB-500 Fragment (17-24) — for research designs that require the isolated activity of the core regulatory sequence without the full-length peptide context.
TB-500 is available in 5mg and 10mg vials as lyophilized powder. Wholesale format, minimum 10 vials per box.
TB-500 acts systemically via G-actin sequestration and is studied for cardiac protection and broad musculoskeletal recovery. BPC-157 acts more locally and is studied for gut protection and tendon/ligament repair. Frequently studied in combination — see Wolverine Blend.
TB-500 is synthesized to 99%+ purity, verified by HPLC and Mass Spectrometry. Every batch is tested by the manufacturer for purity and concentration as part of routine quality control.
Lyophilized TB-500 should be stored at −20°C, away from light and moisture. Aqueous solutions should be kept at 2-8°C and used within 2 weeks.
For laboratory research use only. Not for human or veterinary use. PeptidesFromChina.co is a B2B wholesale supplier operating under strict research-use-only terms. All products are sold exclusively for in vitro and preclinical research purposes.