KPV is a healing & repair research compound currently in stock directly from a verified Chinese manufacturer. Every batch is HPLC-verified and shipped with a Certificate of Analysis (COA). Sourcing is direct — no intermediaries. Minimum order value is $600 USD. International shipping available.
KPV (Lys-Pro-Val) is a tripeptide representing the C-terminal fragment (positions 11-13) of α-Melanocyte-Stimulating Hormone (α-MSH), a naturally occurring anti-inflammatory neuropeptide produced in the hypothalamus and peripheral tissues. Research interest in KPV centers on its apparent ability to replicate the anti-inflammatory signaling of α-MSH through MC1R receptor interaction and intracellular NF-κB pathway inhibition — without the systemic pigmentation effects associated with full-length α-MSH.
Preclinical research has focused on KPV primarily in gastrointestinal inflammation models, including Inflammatory Bowel Disease (IBD) and colitis models, with documented reduction of pro-inflammatory cytokines (TNF-α, IL-6, IL-1β) in animal studies. Its tripeptide structure and resistance to enzymatic degradation in the gut lumen have also made it a subject of oral peptide delivery research targeting intestinal inflammation through a non-hormonal anti-inflammatory pathway.
PeptidesFromChina.co supplies KPV as a lyophilized powder verified to 99%+ purity by HPLC and Mass Spectrometry. Certificate of Analysis is provided with each batch. All products are intended for laboratory research use only and are not for human consumption.
| Chemical Class | α-MSH C-terminal tripeptide (MC1R agonist) |
|---|---|
| Synonyms | α-MSH(11-13), Lys-Pro-Val, L-Lysyl-L-Prolyl-L-Valine |
| Sequence | Lys-Pro-Val |
| Molecular Formula | C₁₆H₃₀N₄O₄ |
| Molecular Weight | 342.4 Da |
| CAS Number | 13454-14-3 |
| Research Areas | Intestinal inflammation, IBD models, gut permeability, NF-κB inhibition, anti-microbial properties, oral delivery research |
| Form | Lyophilized powder |
| Storage | −20°C, protect from light and moisture |
| Name | Strength | Pack Size | Purity | Availability | Price (USD) |
|---|---|---|---|---|---|
| KPV | 10 mg | 10 vials | ≥98% | In Stock | $69.00 |
Testing method: HPLC / LC-MS. Every batch is tested before shipment. Purity ≥99% confirmed per batch.
Certificate of Analysis (COA) is included with every order. Documentation covers purity, molecular weight, and batch identification.
The most studied application of KPV is in gut inflammation models. In vivo colitis models in rodents have examined KPV's anti-inflammatory effects in colonic tissue, with proposed mechanisms involving MC1R agonism, inhibition of NF-κB signaling, and reduction of pro-inflammatory cytokines including TNF-α, IL-6, and IL-1β.
KPV has been examined in models of intestinal barrier dysfunction. Research suggests potential restoration of tight junction protein expression under inflammatory conditions, providing a research model for studying gut permeability via a non-hormonal anti-inflammatory pathway distinct from corticosteroid mechanisms.
Unlike most peptides which are degraded in the GI tract, KPV's tripeptide structure shows relative resistance to enzymatic cleavage, making it a model compound for studying oral peptide delivery strategies targeting intestinal inflammation without systemic absorption requirements.
KPV is supplied as lyophilized powder. Contact us for current availability and vial sizes.
KPV targets anti-inflammatory signaling via MC1R and NF-κB inhibition and is studied specifically for intestinal inflammation (IBD, colitis). BPC-157 is studied for gastroprotection, ulcer models, and gut integrity through different cytoprotective mechanisms. They address different aspects of GI research.
99%+ purity verified by HPLC and Mass Spectrometry. Certificate of Analysis from the originating facility is included with every batch.
Lyophilized KPV should be stored at −20°C, protected from light and moisture.
For laboratory research use only. Not for human or veterinary use. PeptidesFromChina.co is a B2B wholesale supplier operating under strict research-use-only terms. All products are sold exclusively for in vitro and preclinical research purposes.