GHRP-6 is a growth peptides research compound currently in stock directly from a verified Chinese manufacturer. Every batch is HPLC-verified and shipped with a Certificate of Analysis (COA). Sourcing is direct — no intermediaries. Minimum order value is $600 USD. International shipping available.
GHRP-6 (Growth Hormone Releasing Hexapeptide-6) is a synthetic hexapeptide and one of the first-generation growth hormone secretagogues, developed to stimulate pituitary GH release via ghrelin receptor (GHS-R1a) agonism. Its sequence — His-D-Trp-Ala-Trp-D-Phe-Lys-NH₂ — incorporates D-amino acids at positions 2 and 5 to confer resistance to proteolytic degradation, a common feature of synthetic peptide tool compounds. GHRP-6 is widely used in preclinical research as a reference GHS-R1a agonist for establishing receptor pharmacology baselines.
Mechanistically, GHRP-6 acts at the ghrelin receptor (GHS-R1a) to stimulate GH release from anterior pituitary somatotrophs in a pulse-like pattern. Research has examined its effects on GH secretion amplitude, IGF-1 downstream signaling, and interactions with endogenous GHRH (growth hormone-releasing hormone). A notable characteristic of GHRP-6 compared to later GHRPs is its relatively strong ghrelin mimicry — producing appetite stimulation in addition to GH secretion, which has made it a research tool for studying orexigenic signaling alongside GH axis pharmacology.
PeptidesFromChina.co supplies GHRP-6 as a lyophilized powder in sealed vials at 99%+ purity, verified by HPLC and Mass Spectrometry. Certificate of Analysis accompanies every batch. All products are intended for laboratory research use only and are not for human consumption.
| Chemical Class | Synthetic hexapeptide (growth hormone secretagogue) |
|---|---|
| Synonyms | Growth Hormone Releasing Hexapeptide, GHRP 6, SK&F-110679 |
| Sequence | His-D-Trp-Ala-Trp-D-Phe-Lys-NH₂ |
| Amino Acids | 6 |
| Molecular Formula | C₄₆H₅₆N₁₂O₆ |
| Molecular Weight | 873.0 Da |
| CAS Number | 87616-84-0 |
| PubChem CID | 5486806 |
| Receptor Target | GHS-R1a (ghrelin receptor / growth hormone secretagogue receptor) |
| Research Areas | GH axis pharmacology, ghrelin receptor agonism, appetite signaling, pituitary function |
| Form | Lyophilized powder |
| Storage | −20°C long-term; 2-8°C aqueous (use within 2 weeks) |
| Name | Strength | Pack Size | Purity | Availability | Price (USD) |
|---|---|---|---|---|---|
| GHRP-6 | 5 mg | 10 vials | ≥98% | In Stock | $31.00 |
| GHRP-6 | 10 mg | 10 vials | ≥98% | In Stock | $55.00 |
Testing method: HPLC / LC-MS (["LC-MS","HPLC","Water Content"]). Every batch is tested before shipment. Purity ≥99% confirmed per batch.
Certificate of Analysis: Simple COA. Documentation is available for every batch sold.
GHRP-6 is a reference compound in GH axis research, reliably stimulating pulsatile GH release in rodent models via GHS-R1a in anterior pituitary somatotrophs. Studies have examined GH pulse amplitude, duration, and frequency following GHRP-6 administration, as well as synergistic interactions with GHRH analogues (such as CJC-1295). It is commonly used as a pharmacological tool to distinguish GHS-R1a-mediated GH release from GHRH-receptor-mediated mechanisms.
As a high-potency GHS-R1a agonist, GHRP-6 is used to study ghrelin receptor biology including signal transduction, receptor desensitization, and downstream Gq/11 and β-arrestin pathway engagement. Its structural characteristics — particularly D-amino acid substitutions — make it a useful probe for identifying receptor binding requirements and designing improved GHS-R1a ligands.
GHRP-6 produces measurable appetite-stimulating effects in preclinical models, mimicking one of ghrelin's primary biological roles. Research has examined hypothalamic NPY/AgRP pathway activation following GHS-R1a engagement, providing a pharmacological tool for studying the intersection of GH secretion and energy intake regulation — two functions co-regulated by the endogenous ghrelin system.
Both are GHS-R1a agonists but with different potency and side-effect profiles in research models. GHRP-2 generally produces greater GH release amplitude with less appetite stimulation (ghrelin mimicry). GHRP-6 has stronger orexigenic effects due to higher ghrelin receptor efficacy. GHRP-2 is often considered second-generation relative to GHRP-6.
Both approaches are used in research. GHRP-6 alone is a standard GHS-R1a pharmacology tool. In combination with GHRH analogues like CJC-1295 (with or without DAC), synergistic GH pulse amplification has been documented in rodent studies — making the combination a widely used protocol in GH secretagogue research.
GHRP-6 is synthesized to 99%+ purity, verified by HPLC and Mass Spectrometry. Certificate of Analysis from the originating facility is included with every batch.
Lyophilized GHRP-6 should be stored at −20°C. Aqueous solutions should be kept at 2-8°C and used within 2 weeks.
For laboratory research use only. Not for human or veterinary use. PeptidesFromChina.co is a B2B wholesale supplier operating under strict research-use-only terms. All products are sold exclusively for in vitro and preclinical research purposes.