GHRP-6 is a growth peptides research compound currently in stock directly from a verified Chinese manufacturer. Every batch is tested by the manufacturer for purity and concentration as part of routine quality control. Sourcing is direct — no intermediaries. Minimum order value is $600 USD. International shipping available.
GHRP-6 (Growth Hormone Releasing Hexapeptide-6) is a synthetic hexapeptide and one of the first-generation growth hormone secretagogues, developed to stimulate pituitary GH release via ghrelin receptor (GHS-R1a) agonism. Its sequence — His-D-Trp-Ala-Trp-D-Phe-Lys-NH₂ — incorporates D-amino acids at positions 2 and 5 to confer resistance to proteolytic degradation, a common feature of synthetic peptide tool compounds. GHRP-6 is widely used in preclinical research as a reference GHS-R1a agonist for establishing receptor pharmacology baselines.
Mechanistically, GHRP-6 acts at the ghrelin receptor (GHS-R1a) to stimulate GH release from anterior pituitary somatotrophs in a pulse-like pattern. Research has examined its effects on GH secretion amplitude, IGF-1 downstream signaling, and interactions with endogenous GHRH (growth hormone-releasing hormone). A notable characteristic of GHRP-6 compared to later GHRPs is its relatively strong ghrelin mimicry — producing appetite stimulation in addition to GH secretion, which has made it a research tool for studying orexigenic signaling alongside GH axis pharmacology.
PeptidesFromChina.co supplies GHRP-6 as a lyophilized powder in sealed vials at 99%+ purity, verified by HPLC and Mass Spectrometry. Every batch is tested by the manufacturer for purity and concentration as part of routine quality control. All products are intended for laboratory research use only and are not for human consumption.
| Chemical Class | Synthetic hexapeptide (growth hormone secretagogue) |
|---|---|
| Synonyms | Growth Hormone Releasing Hexapeptide, GHRP 6, SK&F-110679 |
| Sequence | His-D-Trp-Ala-Trp-D-Phe-Lys-NH₂ |
| Amino Acids | 6 |
| Molecular Formula | C₄₆H₅₆N₁₂O₆ |
| Molecular Weight | 873.0 Da |
| CAS Number | 87616-84-0 |
| PubChem CID | 5486806 |
| Receptor Target | GHS-R1a (ghrelin receptor / growth hormone secretagogue receptor) |
| Research Areas | GH axis pharmacology, ghrelin receptor agonism, appetite signaling, pituitary function |
| Form | Lyophilized powder |
| Storage | −20°C long-term; 2-8°C aqueous (use within 2 weeks) |
| Name | Strength | Pack Size | Purity | Availability | Price (USD) |
|---|---|---|---|---|---|
| GHRP-6 | 5 mg | 10 vials | ≥98% | In Stock | $31.00 |
| GHRP-6 | 10 mg | 10 vials | ≥98% | In Stock | $55.00 |
Testing method: HPLC / LC-MS (["LC-MS","HPLC","Water Content"]). Every batch is tested before shipment. Purity ≥99% confirmed per batch.
Available documentation: Simple COA. Where provided, these documents reflect the manufacturer's batch testing for this compound.
GHRP-6 is a reference compound in GH axis research, reliably stimulating pulsatile GH release in rodent models via GHS-R1a in anterior pituitary somatotrophs. Studies have examined GH pulse amplitude, duration, and frequency following GHRP-6 administration, as well as synergistic interactions with GHRH analogues (such as CJC-1295). It is commonly used as a pharmacological tool to distinguish GHS-R1a-mediated GH release from GHRH-receptor-mediated mechanisms.
As a high-potency GHS-R1a agonist, GHRP-6 is used to study ghrelin receptor biology including signal transduction, receptor desensitization, and downstream Gq/11 and β-arrestin pathway engagement. Its structural characteristics — particularly D-amino acid substitutions — make it a useful probe for identifying receptor binding requirements and designing improved GHS-R1a ligands.
GHRP-6 produces measurable appetite-stimulating effects in preclinical models, mimicking one of ghrelin's primary biological roles. Research has examined hypothalamic NPY/AgRP pathway activation following GHS-R1a engagement, providing a pharmacological tool for studying the intersection of GH secretion and energy intake regulation — two functions co-regulated by the endogenous ghrelin system.
Both are GHS-R1a agonists but with different potency and side-effect profiles in research models. GHRP-2 generally produces greater GH release amplitude with less appetite stimulation (ghrelin mimicry). GHRP-6 has stronger orexigenic effects due to higher ghrelin receptor efficacy. GHRP-2 is often considered second-generation relative to GHRP-6.
Both approaches are used in research. GHRP-6 alone is a standard GHS-R1a pharmacology tool. In combination with GHRH analogues like CJC-1295 (with or without DAC), synergistic GH pulse amplification has been documented in rodent studies — making the combination a widely used protocol in GH secretagogue research.
GHRP-6 is synthesized to 99%+ purity, verified by HPLC and Mass Spectrometry. Every batch is tested by the manufacturer for purity and concentration as part of routine quality control.
Lyophilized GHRP-6 should be stored at −20°C. Aqueous solutions should be kept at 2-8°C and used within 2 weeks.
For laboratory research use only. Not for human or veterinary use. PeptidesFromChina.co is a B2B wholesale supplier operating under strict research-use-only terms. All products are sold exclusively for in vitro and preclinical research purposes.