GHRP-2 is a growth peptides research compound currently in stock directly from a verified Chinese manufacturer. Every batch is HPLC-verified and shipped with a Certificate of Analysis (COA). Sourcing is direct — no intermediaries. Minimum order value is $600 USD. International shipping available.
GHRP-2 (Growth Hormone Releasing Peptide-2) is a second-generation synthetic hexapeptide and GHS-R1a agonist, developed as an improvement over first-generation secretagogues including GHRP-6. Its sequence — D-Ala-D-2-Nal-Ala-Trp-D-Phe-Lys-NH₂ — incorporates a 2-naphthylalanine residue at position 2 in place of the tryptophan found in GHRP-6, a modification associated with increased receptor binding potency and reduced prolactin-stimulating effects. GHRP-2 is widely used in preclinical research as a reference GH secretagogue with a cleaner pharmacological profile compared to earlier compounds.
In rodent models, GHRP-2 produces robust GH pulse stimulation via GHS-R1a agonism, with documented lower ghrelin receptor efficacy than GHRP-6 — resulting in reduced appetite stimulation while maintaining or enhancing GH secretory amplitude. Research interest includes its use as a pituitary function probe, as a synergistic partner with GHRH analogues, and as a comparison compound for evaluating newer GHS-R1a ligands in structural studies. Its predictable pharmacokinetics and validated effects in multiple species make it a standard research tool.
PeptidesFromChina.co supplies GHRP-2 as a lyophilized powder at 99%+ purity, verified by HPLC and Mass Spectrometry. Certificate of Analysis accompanies every batch. All products are for laboratory research use only and are not for human consumption.
| Chemical Class | Synthetic hexapeptide (second-generation GH secretagogue) |
|---|---|
| Synonyms | Growth Hormone Releasing Peptide-2, Pralmorelin, KP-102 |
| Sequence | D-Ala-D-2-Nal-Ala-Trp-D-Phe-Lys-NH₂ |
| Amino Acids | 6 |
| Molecular Formula | C₄₅H₅₅N₉O₆ |
| Molecular Weight | 817.9 Da |
| CAS Number | 158861-67-7 |
| PubChem CID | 9831531 |
| Receptor Target | GHS-R1a (ghrelin receptor) |
| Research Areas | GH axis pharmacology, pituitary function, GHS-R1a structure-activity, GH deficiency models |
| Form | Lyophilized powder |
| Storage | −20°C long-term; 2-8°C aqueous (use within 2 weeks) |
| Name | Strength | Pack Size | Purity | Availability | Price (USD) |
|---|---|---|---|---|---|
| GHRP-2 | 5 mg | 10 vials | ≥98% | In Stock | $31.00 |
| GHRP-2 | 10 mg | 10 vials | ≥98% | In Stock | $55.00 |
| GHRP-2 | 15 mg | 10 vials | ≥98% | In Stock | $75.00 |
Testing method: HPLC / LC-MS (["HPLC","LC-MS","Water Content"]). Every batch is tested before shipment. Purity ≥99% confirmed per batch.
Certificate of Analysis: Simple COA. Documentation is available for every batch sold.
GHRP-2 reliably stimulates GH release from anterior pituitary somatotrophs in rodent and primate models, making it a standard pituitary function probe. Research has characterized GH pulse profiles following GHRP-2 administration, including peak concentration, pulse duration, and dose-response relationships. It is frequently used in GH deficiency models to assess secretagogue responsiveness as a functional diagnostic tool.
The 2-naphthylalanine substitution in GHRP-2 (replacing tryptophan in GHRP-6) has been of significant interest in GHS-R1a structure-activity relationship studies. Research has compared binding affinities, receptor internalization rates, and downstream signaling profiles between GHRP-2, GHRP-6, and natural ghrelin to map receptor pharmacophore requirements — contributing to rational design of improved GHS-R1a ligands.
GHRP-2 combined with GHRH analogues (CJC-1295, sermorelin) has been extensively studied in GH secretagogue research. The combination engages both GHS-R1a and GHRHR simultaneously, producing synergistic amplification of GH pulses beyond what either agent achieves alone. This synergy has been a primary research design tool for studying GH axis reserve and pituitary responsiveness.
GHRP-2 generally produces greater GH release amplitude and less appetite stimulation (orexigenic effect) than GHRP-6. The 2-naphthylalanine substitution appears to enhance GHS-R1a potency while reducing ghrelin mimicry. GHRP-2 is typically preferred when GH secretion is the primary research endpoint and appetite effects are a confound.
Yes — GHRP-2 and CJC-1295 combination protocols are common in GH axis research. The two compounds engage different receptors (GHS-R1a and GHRHR respectively), and their combination produces synergistic GH pulse amplification in rodent studies. Both are available from PeptidesFromChina.co.
GHRP-2 is synthesized to 99%+ purity, verified by HPLC and Mass Spectrometry. Certificate of Analysis from the manufacturing facility is included with every batch.
Store lyophilized GHRP-2 at −20°C, protected from light and moisture. Aqueous solutions should be kept at 2-8°C and used within 2 weeks.
For laboratory research use only. Not for human or veterinary use. PeptidesFromChina.co is a B2B wholesale supplier operating under strict research-use-only terms. All products are sold exclusively for in vitro and preclinical research purposes.