GHRP-2 is a growth peptides research compound currently in stock directly from a verified Chinese manufacturer. Every batch is tested by the manufacturer for purity and concentration as part of routine quality control. Sourcing is direct — no intermediaries. Minimum order value is $600 USD. International shipping available.
GHRP-2 (Growth Hormone Releasing Peptide-2) is a second-generation synthetic hexapeptide and GHS-R1a agonist, developed as an improvement over first-generation secretagogues including GHRP-6. Its sequence — D-Ala-D-2-Nal-Ala-Trp-D-Phe-Lys-NH₂ — incorporates a 2-naphthylalanine residue at position 2 in place of the tryptophan found in GHRP-6, a modification associated with increased receptor binding potency and reduced prolactin-stimulating effects. GHRP-2 is widely used in preclinical research as a reference GH secretagogue with a cleaner pharmacological profile compared to earlier compounds.
In rodent models, GHRP-2 produces robust GH pulse stimulation via GHS-R1a agonism, with documented lower ghrelin receptor efficacy than GHRP-6 — resulting in reduced appetite stimulation while maintaining or enhancing GH secretory amplitude. Research interest includes its use as a pituitary function probe, as a synergistic partner with GHRH analogues, and as a comparison compound for evaluating newer GHS-R1a ligands in structural studies. Its predictable pharmacokinetics and validated effects in multiple species make it a standard research tool.
PeptidesFromChina.co supplies GHRP-2 as a lyophilized powder at 99%+ purity, verified by HPLC and Mass Spectrometry. Every batch is tested by the manufacturer for purity and concentration as part of routine quality control. All products are for laboratory research use only and are not for human consumption.
| Chemical Class | Synthetic hexapeptide (second-generation GH secretagogue) |
|---|---|
| Synonyms | Growth Hormone Releasing Peptide-2, Pralmorelin, KP-102 |
| Sequence | D-Ala-D-2-Nal-Ala-Trp-D-Phe-Lys-NH₂ |
| Amino Acids | 6 |
| Molecular Formula | C₄₅H₅₅N₉O₆ |
| Molecular Weight | 817.9 Da |
| CAS Number | 158861-67-7 |
| PubChem CID | 9831531 |
| Receptor Target | GHS-R1a (ghrelin receptor) |
| Research Areas | GH axis pharmacology, pituitary function, GHS-R1a structure-activity, GH deficiency models |
| Form | Lyophilized powder |
| Storage | −20°C long-term; 2-8°C aqueous (use within 2 weeks) |
| Name | Strength | Pack Size | Purity | Availability | Price (USD) |
|---|---|---|---|---|---|
| GHRP-2 | 5 mg | 10 vials | ≥98% | In Stock | $31.00 |
| GHRP-2 | 10 mg | 10 vials | ≥98% | In Stock | $55.00 |
| GHRP-2 | 15 mg | 10 vials | ≥98% | In Stock | $75.00 |
Testing method: HPLC / LC-MS (["HPLC","LC-MS","Water Content"]). Every batch is tested before shipment. Purity ≥99% confirmed per batch.
Available documentation: Simple COA. Where provided, these documents reflect the manufacturer's batch testing for this compound.
GHRP-2 reliably stimulates GH release from anterior pituitary somatotrophs in rodent and primate models, making it a standard pituitary function probe. Research has characterized GH pulse profiles following GHRP-2 administration, including peak concentration, pulse duration, and dose-response relationships. It is frequently used in GH deficiency models to assess secretagogue responsiveness as a functional diagnostic tool.
The 2-naphthylalanine substitution in GHRP-2 (replacing tryptophan in GHRP-6) has been of significant interest in GHS-R1a structure-activity relationship studies. Research has compared binding affinities, receptor internalization rates, and downstream signaling profiles between GHRP-2, GHRP-6, and natural ghrelin to map receptor pharmacophore requirements — contributing to rational design of improved GHS-R1a ligands.
GHRP-2 combined with GHRH analogues (CJC-1295, sermorelin) has been extensively studied in GH secretagogue research. The combination engages both GHS-R1a and GHRHR simultaneously, producing synergistic amplification of GH pulses beyond what either agent achieves alone. This synergy has been a primary research design tool for studying GH axis reserve and pituitary responsiveness.
GHRP-2 generally produces greater GH release amplitude and less appetite stimulation (orexigenic effect) than GHRP-6. The 2-naphthylalanine substitution appears to enhance GHS-R1a potency while reducing ghrelin mimicry. GHRP-2 is typically preferred when GH secretion is the primary research endpoint and appetite effects are a confound.
Yes — GHRP-2 and CJC-1295 combination protocols are common in GH axis research. The two compounds engage different receptors (GHS-R1a and GHRHR respectively), and their combination produces synergistic GH pulse amplification in rodent studies. Both are available from PeptidesFromChina.co.
GHRP-2 is synthesized to 99%+ purity, verified by HPLC and Mass Spectrometry. Every batch is tested by the manufacturer for purity and concentration as part of routine quality control.
Store lyophilized GHRP-2 at −20°C, protected from light and moisture. Aqueous solutions should be kept at 2-8°C and used within 2 weeks.
For laboratory research use only. Not for human or veterinary use. PeptidesFromChina.co is a B2B wholesale supplier operating under strict research-use-only terms. All products are sold exclusively for in vitro and preclinical research purposes.