SNAP-8 is a skin & hair research compound currently in stock directly from a verified Chinese manufacturer. Every batch is HPLC-verified and shipped with a Certificate of Analysis (COA). Sourcing is direct — no intermediaries. Minimum order value is $600 USD. International shipping available.
SNAP-8 (Acetyl Octapeptide-3) is a synthetic octapeptide functionally related to the N-terminal peptide region of SNAP-25 (synaptosomal-associated protein 25), a key component of the SNARE complex responsible for neurotransmitter vesicle fusion at synaptic terminals. The SNARE complex also mediates catecholamine release from cutaneous neuronal junctions, which drives contraction of expression muscles. By providing a competitive analogue of the SNAP-25 binding site, SNAP-8 is studied as a potential inhibitor of SNARE complex assembly at the neuro-muscular junction — a mechanism proposed to reduce muscle contraction amplitude at the site of application.
Research into SNAP-8 examines its ability to inhibit catecholamine exocytosis from neuronal terminals in skin — specifically, the noradrenaline release that triggers receptor-mediated muscle fiber contraction. In contrast to botulinum toxin, which cleaves SNAP-25 irreversibly, SNAP-8 provides a reversible competitive peptide that can be used to study SNARE-mediated exocytosis in dermal research models without permanent enzymatic destruction of the SNARE machinery. Research applications include studies of neuro-muscular junction pharmacology in skin, SNARE complex assembly kinetics, and catecholamine exocytosis modulation in cutaneous tissues.
PeptidesFromChina.co supplies SNAP-8 as a lyophilized powder at 99%+ purity, verified by HPLC and Mass Spectrometry. Certificate of Analysis accompanies every batch. All products are for laboratory research use only and are not for human consumption.
| Chemical Class | Synthetic octapeptide / SNARE complex competitive analogue |
|---|---|
| Synonyms | Acetyl Octapeptide-3, Leuphasyl, SNAP-8 peptide |
| Sequence | Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH₂ |
| Amino Acids | 8 |
| Molecular Weight | ~1075 Da |
| Research Areas | SNARE complex pharmacology, catecholamine exocytosis, neuro-muscular junction research, skin biology |
| Form | Lyophilized powder |
| Storage | −20°C long-term; 2-8°C aqueous (use within 2 weeks) |
| CAS Number | 868844-74-0 |
| Molecular Formula | C₄₈H₇₁N₁₃O₁₄S |
| Name | Strength | Pack Size | Purity | Availability | Price (USD) |
|---|---|---|---|---|---|
| SNAP-8 | 10 mg | 10 vials | ≥98% | In Stock | $49.00 |
Testing method: HPLC / LC-MS. Every batch is tested before shipment. Purity ≥99% confirmed per batch.
Certificate of Analysis (COA) is included with every order. Documentation covers purity, molecular weight, and batch identification.
SNAP-8 provides a research tool for studying SNARE complex-dependent exocytosis without the irreversible proteolytic mechanism of botulinum toxins. Research has examined SNAP-8's ability to compete with endogenous SNAP-25 in SNARE complex assembly assays, measuring its inhibitory constant (IC₅₀) against SNARE zippering in reconstituted membrane fusion systems. This competitive, reversible inhibition makes SNAP-8 useful for dose-response studies where SNARE complex formation must be titrated rather than abolished.
Skin neuro-muscular junctions release noradrenaline via SNARE-dependent exocytosis to stimulate expression muscle fibers. Research using SNAP-8 in skin culture models and ex vivo tissue preparations has examined whether SNARE complex inhibition reduces catecholamine release, muscle contraction markers, and downstream extracellular matrix changes at the neuronal junction. These studies provide mechanistic context for the compound's proposed dermatological applications.
The minimal SNAP-25 sequence required for SNARE complex binding and inhibition has been studied using truncated and modified SNAP-25 peptide fragments. SNAP-8 represents a well-characterized octapeptide probe in this structure-activity space. Comparative studies with shorter or longer SNAP-25 fragments help define the binding pharmacophore required for competitive SNARE inhibition — contributing to peptide design research in the SNARE biology field.
Botulinum toxin cleaves SNAP-25 proteolytically — an irreversible mechanism that permanently destroys the SNARE component. SNAP-8 is a competitive peptide analogue that transiently occupies the SNAP-25 binding site in the SNARE complex — a reversible mechanism that can be titrated and allows SNARE function to recover. SNAP-8 is used in research when reversible, dose-dependent SNARE inhibition is required rather than permanent inactivation.
SNAP-25 (synaptosomal-associated protein 25) is a core SNARE complex component essential for synaptic vesicle fusion and neurotransmitter/catecholamine exocytosis. It is expressed in neurons throughout the CNS and PNS, including cutaneous neuronal terminals. Research into SNAP-25 pharmacology — via SNAP-8 as a competitive inhibitor — provides insights into how SNARE complex assembly can be modulated pharmacologically.
SNAP-8 is synthesized to 99%+ purity, verified by HPLC and Mass Spectrometry. Certificate of Analysis from the manufacturing facility is included with every batch.
Lyophilized SNAP-8 should be stored at −20°C, protected from moisture and light. Aqueous solutions should be kept at 2-8°C and used within 2 weeks.
For laboratory research use only. Not for human or veterinary use. PeptidesFromChina.co is a B2B wholesale supplier operating under strict research-use-only terms. All products are sold exclusively for in vitro and preclinical research purposes.