Relaxation PM is a cognitive & neuro research compound currently in stock directly from a verified Chinese manufacturer. Every batch is tested by the manufacturer for purity and concentration as part of routine quality control. Sourcing is direct — no intermediaries. Public catalog minimum is $300 in goods per supplier. Eligible new customers may use one first-order trial without a monetary minimum; 5% off goods applies from $3,500 per supplier, excluding shipping. International shipping available.
Relaxation PM is a compounded injectable formulation containing GABA 100 mg, Melatonin 1 mg, L-Arginine 100 mg, and L-Glutamine 25 mg per ml. The formulation targets GABAergic pathway modulation, circadian rhythm signaling, and neurotransmitter-associated metabolic mechanisms in preclinical research contexts.
Each component has a defined neurological or metabolic research role: GABA (γ-aminobutyric acid) is the primary inhibitory neurotransmitter in the mammalian central nervous system, acting on GABA-A (ionotropic, Cl⁻ channel) and GABA-B (metabotropic, K⁺/Ca²⁺) receptors; Melatonin is the pineal hormone that regulates circadian rhythm via MT1 and MT2 melatonin receptors, with additional antioxidant activity as a hydroxyl radical scavenger; L-Arginine is the substrate for neuronal nitric oxide synthase (nNOS) and is studied in neurological contexts for NO-mediated synaptic signaling; L-Glutamine is the primary brain ammonia buffer and an inter-organ nitrogen carrier, serving as a precursor for both glutamate and GABA synthesis.
PeptidesFromChina.co supplies Relaxation PM as a sterile liquid formulation with component concentrations verified by the manufacturer per batch. For laboratory research use only.
| Components per ml | GABA 100 mg, Melatonin 1 mg, L-Arginine 100 mg, L-Glutamine 25 mg |
|---|---|
| Volume | 10 ml vial |
| Research Axes | GABAergic inhibitory signaling, circadian rhythm / MT1/MT2, nNOS/NO pathway, glutamine-GABA precursor cycle |
| Chemical Class | Neurotransmitter and neuromodulator injectable combination |
| Research Areas | GABAergic neuropharmacology, circadian biology, neuronal NO signaling, sleep/wake cycle research, ammonia metabolism |
| Form | Sterile liquid formulation |
| Storage | 2-8°C; protect from light; do not freeze |
| Sequence | N/A — complex mixture |
| CAS Number | N/A — complex mixture |
| Molecular Formula | N/A — complex mixture |
| Molecular Weight | N/A — complex mixture |
| Name | Strength | Pack Size | Purity | Availability | Price (USD) |
|---|---|---|---|---|---|
| Relaxation PM | 10 ml | 10 vials | >=98% | In Stock | $74.00 |
Testing method: HPLC / LC-MS. Products are supplied against the specification shown on the applicable product page. The standard catalog purity specification is ≥98% unless otherwise stated. Product-specific specifications and quality-control information may vary by compound and batch.
Every batch is tested by the manufacturer for purity and concentration as part of routine quality control, using methods such as HPLC and LC-MS. These results are kept in the manufacturer's internal quality-control records and are not issued as a separate certificate or document.
GABA-A and GABA-B receptor pharmacology is studied in neuronal cell cultures (primary cortical neurons, GABAergic interneuron preparations) and brain slice preparations. GABA-A receptor modulation (chloride conductance, inhibitory postsynaptic potential frequency and amplitude) and GABA-B receptor signaling (Gi/o-coupled K⁺ channel activation, Ca²⁺ channel inhibition) are measured electrophysiologically. The Glutamine-Glutamate-GABA cycle — where Glutamine is converted by glutaminase to Glutamate and then by GAD (glutamic acid decarboxylase) to GABA — is an additional research axis provided by the L-Glutamine component.
Melatonin acts on MT1 receptors to suppress SCN (suprachiasmatic nucleus) firing and on MT2 receptors to phase-shift the circadian clock. Research using melatonin examines receptor binding kinetics (radioligand displacement with 2-[¹²⁵I]-iodomelatonin), circadian phase resetting (Per1/Per2 gene expression in circadian reporter cell lines), and antioxidant activity (ORAC, DPPH assays). Combined with GABA (which also modulates SCN activity via GABA-A receptors), the formulation provides dual inhibitory tone for sleep-related neurophysiology research.
Primary research areas include: GABAergic neuropharmacology (GABA-A/B receptor studies in neuronal models), circadian rhythm biology (melatonin MT1/MT2 receptor pharmacology, circadian phase shifting), neuronal NO signaling (nNOS substrate with L-Arginine), and glutamine-GABA metabolic cycling. The combination is also used in sleep-wake cycle research examining the combined inhibitory effects of GABA and Melatonin on SCN activity.
Endogenous GABA has limited CNS penetration via systemic administration under normal physiological conditions due to low BBB permeability. In vitro and ex vivo neurological research — using primary neuronal cultures, brain slice preparations, or direct CNS administration models — circumvents this limitation. For systemic research designs examining peripheral GABA receptor systems (enteric nervous system, immune cells), the compound is studied in those peripheral contexts directly.
Relaxation PM should be stored at 2-8°C, protected from light. Do not freeze. Use within the date specified on the label.
For laboratory research use only. Not for human or veterinary use. PeptidesFromChina.co is a B2B wholesale supplier operating under strict research-use-only terms. All products are sold exclusively for in vitro and preclinical research purposes.