Pinealon is a cognitive & neuro research compound currently in stock directly from a verified Chinese manufacturer. Every batch is HPLC-verified and shipped with a Certificate of Analysis (COA). Sourcing is direct — no intermediaries. Minimum order value is $600 USD. International shipping available.
Pinealon (Glu-Asp-Arg) is a synthetic tripeptide bioregulator developed from research into peptide fractions of the pineal gland. It belongs to a class of short peptide bioregulators studied for their proposed tissue-specific effects on gene expression regulation — the concept underlying the cytomax and peptide bioregulator research programs originating in Russian gerontology research. Pinealon is the shortest member of the pineal peptide series, and research has examined its interactions with deoxyribonucleic acid sequences and chromatin-associated proteins, with proposed specificity for regulatory regions in the promoters of genes relevant to pineal and neuronal function.
Research interest in pinealon spans neuroprotection, circadian regulation, and cellular stress response. In vitro studies have examined pinealon's effects on neuronal cell cultures under conditions of oxidative stress — measuring cell viability markers, mitochondrial potential, and apoptosis rate. Animal studies have assessed cognitive and behavioral outcomes in aged rodent models, examining whether pinealon affects hippocampal neuron morphology, memory performance, and circadian behavioral parameters. Proposed mechanisms include regulation of gene transcription via DNA interaction and modulation of oxidative metabolism.
PeptidesFromChina.co supplies Pinealon as a lyophilized powder at 99%+ purity, verified by HPLC and Mass Spectrometry. Certificate of Analysis accompanies every batch. All products are for laboratory research use only and are not for human consumption.
| Chemical Class | Synthetic tripeptide bioregulator (pineal origin) |
|---|---|
| Synonyms | Glu-Asp-Arg tripeptide, EDR, pineal bioregulator peptide |
| Sequence | Glu-Asp-Arg |
| Amino Acids | 3 |
| Molecular Weight | 432.4 Da |
| Research Areas | Neuroprotection, circadian biology, aging research, gene expression modulation, oxidative stress |
| Form | Lyophilized powder |
| Storage | −20°C long-term; 2-8°C aqueous (use within 2 weeks) |
| Molecular Formula | C₁₄H₂₅N₅O₉ (Glu-Asp-Arg) |
| CAS Number | Available on COA |
| Name | Strength | Pack Size | Purity | Availability | Price (USD) |
|---|---|---|---|---|---|
| Pinealon | 10 mg | 10 vials | ≥98% | In Stock | $49.00 |
Testing method: HPLC / LC-MS (["HPLC","LC-MS","Water Content"]). Every batch is tested before shipment. Purity ≥99% confirmed per batch.
Certificate of Analysis: Simple COA. Documentation is available for every batch sold.
Research has examined pinealon's effects on neuronal cell viability under oxidative challenge conditions — hydrogen peroxide exposure, glutamate toxicity, and serum deprivation models. Studies have measured mitochondrial membrane potential, ROS levels, and apoptosis markers (caspase-3, PARP cleavage) in neurons treated with pinealon versus vehicle controls. The proposed neuroprotective mechanism involves regulation of antioxidant gene expression and mitochondrial protective pathways.
Pinealon's derivation from pineal research connects it to circadian biology — the pineal gland synthesizes melatonin under SCN control and is central to circadian timekeeping. Research has examined whether pinealon affects melatonin synthesis enzymes (AANAT, ASMT) in pinealocyte cultures, and whether its administration alters circadian behavioral parameters (locomotor activity rhythms) in aged rodents where circadian amplitude typically declines.
Pinealon is studied within the broader framework of peptide bioregulator research for aging, where short peptides derived from specific glands or tissues are proposed to restore age-related decline in target organ function. Research protocols in aged rodent models have examined cognitive performance (Morris water maze, radial arm maze), brain morphology (hippocampal neuron density), and oxidative damage markers following pinealon treatment — contributing to the mechanistic evaluation of peptide bioregulators in gerontology research.
Peptide bioregulators are short (2-4 amino acid) peptides proposed to regulate gene expression in tissue-specific patterns. The research concept, developed primarily in Russian gerontology, suggests that these peptides interact directly with gene regulatory elements to restore tissue function declining with age. Pinealon is the pineal-derived representative — a Glu-Asp-Arg tripeptide studied for neurological and circadian effects consistent with pineal gland biology.
While melatonin is the primary hormone product of the pineal gland, pinealon research focuses on upstream regulatory peptides proposed to maintain pineal function and melatonin synthesis capacity. In vitro studies have examined whether pinealon affects AANAT (arylalkylamine N-acetyltransferase) expression — the rate-limiting enzyme in melatonin biosynthesis — as a mechanistic endpoint.
Pinealon is synthesized to 99%+ purity, verified by HPLC and Mass Spectrometry. Certificate of Analysis from the manufacturing facility is included with every batch.
Lyophilized pinealon should be stored at −20°C. Aqueous solutions should be kept at 2-8°C and used within 2 weeks. The tripeptide is generally stable in neutral aqueous conditions.
For laboratory research use only. Not for human or veterinary use. PeptidesFromChina.co is a B2B wholesale supplier operating under strict research-use-only terms. All products are sold exclusively for in vitro and preclinical research purposes.