MOTS-C is a metabolic & longevity research compound currently in stock directly from a verified Chinese manufacturer. Every batch is HPLC-verified and shipped with a Certificate of Analysis (COA). Sourcing is direct — no intermediaries. Minimum order value is $600 USD. International shipping available.
MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA type-c) is a 16-amino acid mitochondrial-derived peptide (MDP) — a class of bioactive peptides encoded by short open reading frames within the mitochondrial genome, termed mitokines. MOTS-c is encoded by the 12S ribosomal RNA gene and was first characterized in 2015 by Lee et al. at the University of Southern California. It is notable for being translated within mitochondria and capable of translocating to the nucleus, acting as a regulator of gene expression and energy metabolism.
Preclinical research has focused on MOTS-c in the context of metabolic regulation and glucose homeostasis. Rodent studies have shown that MOTS-c administration activates AMPK, inhibits the folate-methionine cycle, and results in improved insulin sensitivity and reduced adiposity in diet-induced obesity models. Age-related decline of MOTS-c in plasma has been observed in both rodent and human observational data, positioning it within longevity and metabolic aging research as an exercise-mimetic compound.
PeptidesFromChina.co supplies MOTS-c as a lyophilized powder at 5mg concentration, synthesized to 99%+ purity by HPLC and Mass Spectrometry. Certificate of Analysis provided with each batch. All products are intended for laboratory research use only and are not for human consumption.
| Chemical Class | Mitochondrial-derived peptide (MDP / Mitokine) |
|---|---|
| Sequence | MRWQEMGYIFYPRKLR |
| Amino Acids | 16 |
| Molecular Weight | ~2174 Da |
| CAS Number | 1627580-64-6 |
| Research Areas | Metabolic regulation, insulin sensitivity, AMPK activation, glucose metabolism, skeletal muscle, aging biology, exercise-mimetic research |
| Form | Lyophilized powder |
| Storage | −20°C, protect from light and moisture |
| Molecular Formula | N/A — 16-aa mitochondria-derived peptide; see COA |
| Name | Strength | Pack Size | Purity | Availability | Price (USD) |
|---|---|---|---|---|---|
| MOTS-C | 10 mg | 10 vials | ≥98% | In Stock | $69.00 |
| MOTS-C | 20 mg | 10 vials | ≥98% | Out of Stock | $138.00 |
| MOTS-C | 40 mg | 10 vials | ≥98% | In Stock | $207.00 |
Testing method: HPLC / LC-MS. Every batch is tested before shipment. Purity ≥99% confirmed per batch.
Certificate of Analysis (COA) is included with every order. Documentation covers purity, molecular weight, and batch identification.
The primary area of MOTS-c research is metabolic disease. In diet-induced obesity mouse models, systemic MOTS-c administration activated AMPK and modulated the folate-methionine cycle, resulting in improved insulin sensitivity, reduced adiposity, and improved glucose metabolism. These findings position MOTS-c as a candidate for further research in type 2 diabetes and metabolic syndrome models.
MOTS-c is naturally elevated in skeletal muscle following exercise in animal models, classifying it as a potential exercise-mimetic mitokine. Exogenous administration has been shown to improve exercise capacity and delay fatigue in rodent models, with proposed mechanisms involving mitochondrial efficiency and metabolite regulation relevant to skeletal muscle energy homeostasis.
Age-related decline in circulating MOTS-c has been documented in both rodent and limited human observational data. Longevity researchers have examined MOTS-c in the context of metabolic homeostasis and healthspan, as its mitochondrial origin connects it directly to mitochondrial decline theories of aging at the molecular level.
MOTS-c is available in 5mg vials as lyophilized powder.
MOTS-c is a mitochondrially-encoded peptide acting via AMPK activation and folate-methionine cycle modulation. Semaglutide is a GLP-1 receptor agonist acting on incretin pathways for glucose-dependent insulin secretion. Completely different mechanisms, research contexts, and receptor targets.
99%+ purity verified by HPLC and Mass Spectrometry. Certificate of Analysis from the originating facility is included with every batch.
Lyophilized MOTS-c should be stored at −20°C, protected from light and moisture.
For laboratory research use only. Not for human or veterinary use. PeptidesFromChina.co is a B2B wholesale supplier operating under strict research-use-only terms. All products are sold exclusively for in vitro and preclinical research purposes.