KissPeptin-10 is a hormonal regulation research compound currently in stock directly from a verified Chinese manufacturer. Every batch is HPLC-verified and shipped with a Certificate of Analysis (COA). Sourcing is direct — no intermediaries. Minimum order value is $600 USD. International shipping available.
Kisspeptin-10 is the C-terminal decapeptide of kisspeptin (also known as metastin), the endogenous neuropeptide product of the KISS1 gene. Kisspeptins are processed from a 145-amino acid precursor into fragments of varying lengths (kisspeptin-54, -14, -13, -10), all of which share the C-terminal decapeptide sequence that is required for GPR54/KISS1R receptor binding. Kisspeptin-10 — the minimally active binding fragment — is the most widely used research form due to its small size, ease of synthesis, and equipotent activity to longer kisspeptin isoforms at GPR54.
Kisspeptin and GPR54 are essential regulators of the hypothalamic-pituitary-gonadal (HPG) axis. Kisspeptin neurons in the arcuate nucleus and anteroventral periventricular nucleus (AVPV) integrate sex steroid feedback signals and project directly onto GnRH (gonadotropin-releasing hormone) neurons, stimulating GnRH pulse release. Loss-of-function mutations in KISS1 or GPR54 result in hypogonadotropic hypogonadism in rodents and humans — establishing kisspeptin/GPR54 as the upstream activator of reproductive endocrine function. Research applications include HPG axis physiology, puberty onset mechanisms, seasonal reproduction biology, and fertility research.
PeptidesFromChina.co supplies Kisspeptin-10 as a lyophilized powder at 99%+ purity, verified by HPLC and Mass Spectrometry. Certificate of Analysis accompanies every batch. All products are for laboratory research use only and are not for human consumption.
| Chemical Class | RFamide neuropeptide (C-terminal kisspeptin fragment) |
|---|---|
| Synonyms | KP-10, Metastin(45-54), KISS1 C-terminal decapeptide |
| Sequence | Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH₂ |
| Amino Acids | 10 |
| Molecular Weight | 1302.6 Da |
| CAS Number | 374683-16-6 |
| Receptor Target | GPR54 / KISS1R (kisspeptin receptor) |
| Research Areas | HPG axis physiology, GnRH pulse regulation, puberty biology, reproductive neuroendocrinology, fertility research |
| Form | Lyophilized powder |
| Storage | −20°C long-term; 2-8°C aqueous (use within 2 weeks) |
| Molecular Formula | C₆₅H₈₃N₁₅O₁₃ |
| Name | Strength | Pack Size | Purity | Availability | Price (USD) |
|---|---|---|---|---|---|
| KissPeptin-10 | 5 mg | 10 vials | ≥98% | In Stock | $75.00 |
| KissPeptin-10 | 10 mg | 10 vials | ≥98% | In Stock | $94.00 |
Testing method: HPLC / LC-MS (["HPLC","LC-MS","Endotoxins","Assay","Water Content"]). Every batch is tested before shipment. Purity ≥99% confirmed per batch.
Certificate of Analysis: Manufacturer COA. Documentation is available for every batch sold.
Kisspeptin-10 is a primary research tool for studying GnRH neuron activation. Studies in rodent and sheep models have characterized the dose-response relationship between kisspeptin-10 administration and GnRH pulse frequency/amplitude, LH surge induction, and ovulation. Arcuate nucleus kisspeptin neuron populations co-express NKB and dynorphin (KNDy neurons), forming the pulse-generating circuit for GnRH. Kisspeptin-10 is used to pharmacologically test GPR54 responsiveness of GnRH neurons in these circuit studies.
Kisspeptin signaling is essential for the hormonal changes that trigger puberty. Research has examined how kisspeptin neuronal activity increases during prepuberty, how sex steroid feedback regulates arcuate and AVPV kisspeptin neuron populations, and how kisspeptin-10 administration to prepubertal rodents can advance puberty onset. These studies contribute to understanding of the neuroendocrine switch that initiates the HPG axis activation at puberty.
In seasonally breeding mammals (sheep, hamsters), kisspeptin neuronal populations in the arcuate nucleus undergo photoperiod-dependent changes that regulate seasonal HPG axis activity. Research has used kisspeptin-10 administration to test GPR54 responsiveness across reproductive seasons and examined whether exogenous kisspeptin can override photoperiodic suppression. This seasonal reproduction research provides insights into how the kisspeptin system integrates environmental signals with reproductive timing.
Kisspeptin-10 (the C-terminal decapeptide) contains the minimal sequence required for GPR54 binding and activation — the RFamide-related C-terminal motif (-Arg-Phe-NH₂). Full-length kisspeptin-54 has equivalent activity at GPR54 per mole, but kisspeptin-10 is easier and less expensive to synthesize, more stable, and equally potent per receptor. It is the standard research form for GPR54 pharmacology.
The pre-ovulatory LH surge in females is driven by a surge in kisspeptin release from AVPV kisspeptin neurons in response to rising estradiol (positive feedback). This kisspeptin surge activates GnRH neurons, producing the GnRH pulse that triggers LH surge from the pituitary. Kisspeptin-10 is used to model this signaling event pharmacologically in research.
Kisspeptin-10 is synthesized to 99%+ purity, verified by HPLC and Mass Spectrometry. Certificate of Analysis from the manufacturing facility is included with every batch.
Lyophilized Kisspeptin-10 should be stored at −20°C. Aqueous solutions should be kept at 2-8°C and used within 2 weeks.
For laboratory research use only. Not for human or veterinary use. PeptidesFromChina.co is a B2B wholesale supplier operating under strict research-use-only terms. All products are sold exclusively for in vitro and preclinical research purposes.