Ipamorelin is a growth peptides research compound currently in stock directly from a verified Chinese manufacturer. Every batch is HPLC-verified and shipped with a Certificate of Analysis (COA). Sourcing is direct — no intermediaries. Minimum order value is $600 USD. International shipping available.
Ipamorelin is a synthetic pentapeptide (five amino acids) that acts as a selective agonist at the ghrelin receptor (GHSR-1a), classified as a growth hormone releasing peptide (GHRP). Its sequence — Aib-His-D-2-Nal-D-Phe-Lys-NH₂ — includes non-natural amino acid substitutions (Aib at position 1, D-2-naphthylalanine at position 3) that confer receptor selectivity and resistance to peptidase degradation relative to earlier GHRPs such as GHRP-6 and GHRP-2. The key pharmacological distinction is ipamorelin's minimal effect on cortisol and prolactin — a selectivity profile established in rat pituitary cell studies and confirmed in human volunteer pharmacodynamic trials.
Preclinical research characterises ipamorelin primarily through its stimulation of pulsatile growth hormone release from anterior pituitary somatotrophs via GHSR-1a activation and secondary GH-releasing hormone (GHRH) synergism. When co-administered with a GHRH analogue (most commonly CJC-1295 without DAC), GH pulse amplitude is substantially amplified through complementary receptor pathways — making the Ipamorelin + CJC-1295 combination one of the most studied GH secretagogue pairings in both rodent and primate models. IGF-1 elevation downstream of GH release is monitored as a secondary endpoint in most preclinical growth models.
PeptidesFromChina.co supplies research-grade ipamorelin as lyophilized powder in sealed vials at ≥98% purity, verified by HPLC and mass spectrometry. Batch Certificates of Analysis are available. Wholesale orders are accommodated on request. This compound is for laboratory research use only.
| Chemical Class | Growth Hormone Releasing Peptide (GHRP) |
|---|---|
| CAS Number | 170851-70-4 |
| Molecular Formula | C₃₈H₄₉N₉O₅ |
| Molecular Weight | 711.85 Da |
| Sequence | Aib-His-D-2Nal-D-Phe-Lys-NH₂ (5 amino acids) |
| Receptor Target | GHSR-1a (Ghrelin receptor) |
| Synonyms | NNC 26-0161 |
| Half-life (research) | ~2 h (rodent, i.v.) |
| Storage | -20°C lyophilized; 4°C reconstituted (up to 14 days) |
| Name | Strength | Pack Size | Purity | Availability | Price (USD) |
|---|---|---|---|---|---|
| Ipamorelin | 5 mg | 10 vials | ≥98% | In Stock | $44.00 |
| Ipamorelin | 10 mg | 10 vials | ≥98% | In Stock | $63.00 |
Testing method: HPLC / LC-MS. Every batch is tested before shipment. Purity ≥99% confirmed per batch.
Certificate of Analysis (COA) is included with every order. Documentation covers purity, molecular weight, and batch identification.
Ipamorelin's GHSR-1a selectivity makes it a useful pharmacological tool for investigating somatotroph function and pulsatile GH secretion. In primary rat pituitary cell cultures, ipamorelin induces concentration-dependent GH release without significant co-stimulation of ACTH, cortisol, or prolactin — a specificity profile useful for isolating GH-axis effects in mechanistic studies. Combined administration with GHRH analogues (particularly CJC-1295 without DAC) produces synergistic GH release, as the two compounds act via independent receptor pathways (GHSR-1a vs. GHRHR).
Rodent studies using GH-deficient models (hypophysectomised rats, dwarf rats) demonstrate that ipamorelin administration partially restores lean body mass, bone mineral density, and linear growth at doses that do not suppress endogenous GH axis feedback as severely as exogenous GH. The selectivity for somatotrophs over corticotrophs is particularly relevant when modelling the long-term effects of GH axis stimulation in metabolic phenotyping studies.
Ghrelin receptors (GHSR-1a) are expressed throughout the enteric nervous system and GI smooth muscle. Preclinical studies document that GHSR-1a agonists including ipamorelin accelerate gastric emptying in rodent models of post-operative and diabetic gastroparesis. Ipamorelin's clean cortisol profile makes it a preferred tool compound versus GHRP-6 (which has significant ghrelin/orexigenic activity and cortisol effects) in GI motility mechanistic studies.
GH and IGF-1 are established anabolic regulators of bone matrix deposition and periosteal expansion. Ipamorelin-induced GH secretion in ovariectomised rat models of oestrogen deficiency-associated bone loss has been studied in the context of GH axis reactivation strategies. Elevated IGF-1 downstream of GH release stimulates osteoblast differentiation and collagen synthesis in in vitro calvarial osteoblast assays.
Both are GHSR-1a agonists but differ substantially in selectivity. GHRP-6 also stimulates ghrelin-associated appetite signalling and produces significant cortisol and prolactin elevation in preclinical models. Ipamorelin is selective for pituitary somatotrophs with minimal cortisol, prolactin, or appetite-hormone cross-reactivity — making it the preferred tool compound when researchers wish to isolate GH-axis effects without confounding neuroendocrine activity.
Ipamorelin (GHSR-1a agonist) and CJC-1295 without DAC (GHRH receptor agonist) stimulate GH release via distinct receptors. When combined, the two pathways act synergistically — producing GH pulse amplitudes substantially greater than either compound alone. This combination is widely used in preclinical GH secretagogue studies to maximise GH output while minimising dose of either individual agent.
Store lyophilized ipamorelin at -20°C, protected from moisture and UV light. Reconstituted solutions in bacteriostatic water are stable at 4°C for up to 14 days. For longer-term storage of reconstituted peptide, aliquot and store at -80°C, avoiding repeated freeze-thaw cycles.
Yes. PeptidesFromChina.co supplies ipamorelin in wholesale quantities with tiered pricing. Standard vial sizes and pricing are available on request after account verification. Contact us via the request form.
For laboratory research use only. Not for human or veterinary use. PeptidesFromChina.co is a B2B wholesale supplier operating under strict research-use-only terms. All products are sold exclusively for in vitro and preclinical research purposes.