HMG is a hormonal regulation research compound currently in stock directly from a verified Chinese manufacturer. Every batch is HPLC-verified and shipped with a Certificate of Analysis (COA). Sourcing is direct — no intermediaries. Minimum order value is $600 USD. International shipping available.
HMG (Human Menopausal Gonadotropin) is a purified gonadotropin preparation derived from the urine of post-menopausal women, containing a mixture of FSH (follicle-stimulating hormone) and LH (luteinizing hormone) activity in approximately equal proportions. Post-menopausal urine contains elevated gonadotropin concentrations due to loss of ovarian feedback inhibition on the hypothalamic-pituitary axis. HMG preparations are standardized by bioassay to defined FSH and LH activity units, providing a clinically and experimentally relevant preparation that reproduces the combined gonadotropin stimulation required for full gonadal function.
Research applications for HMG center on reproductive endocrinology, gonadal physiology, and fertility biology. In female models, FSH stimulates follicular development (granulosa cell proliferation, estradiol production, follicle growth), while LH triggers ovulation and luteinization. HMG provides simultaneous FSH and LH stimulation, which more closely models physiological gonadotropin co-stimulation than individual recombinant preparations. Rodent superovulation protocols using HMG followed by hCG (human chorionic gonadotropin — LH analogue) are standard research designs for producing large numbers of oocytes for assisted reproduction and developmental biology research.
PeptidesFromChina.co supplies HMG at standardized gonadotropin activity, verified by activity assay. Certificate of Analysis accompanies every batch. All products are for laboratory research use only and are not for human consumption.
| Chemical Class | Urinary gonadotropin preparation (glycoprotein hormone mixture) |
|---|---|
| Synonyms | Human Menopausal Gonadotropin, Menotropins, uFSH+LH |
| Active Components | FSH (follicle-stimulating hormone) + LH (luteinizing hormone), approximately 1:1 ratio |
| Standardization | Defined FSH and LH IU activity per vial |
| Research Areas | Reproductive endocrinology, folliculogenesis, superovulation protocols, fertility biology, gonadotropin pharmacology |
| Form | Lyophilized powder |
| Storage | 2-8°C dry storage; −20°C long-term; reconstituted solutions use within 24 hours |
| CAS Number | N/A — complex mixture |
| Molecular Weight | N/A — complex mixture |
| Molecular Formula | N/A — complex mixture |
| Sequence | N/A — complex mixture |
| Name | Strength | Pack Size | Purity | Availability | Price (USD) |
|---|---|---|---|---|---|
| HMG | 75 IU | 10 vials | ≥98% | In Stock | $69.00 |
Testing method: HPLC / LC-MS. Every batch is tested before shipment. Purity ≥99% confirmed per batch.
Certificate of Analysis (COA) is included with every order. Documentation covers purity, molecular weight, and batch identification.
FSH is the primary driver of follicular development — stimulating granulosa cell proliferation, aromatase expression, and estradiol production in developing follicles. Research using HMG in rodent and large animal models has characterized the dose-response relationship between exogenous gonadotropin levels and follicle number, size distribution, estradiol output, and oocyte quality. These studies contribute to understanding of FSH signaling thresholds and follicular response heterogeneity.
Rodent superovulation using HMG (to stimulate follicular development) followed by hCG (to trigger ovulation) is the standard protocol for producing large oocyte cohorts in mice and rats for in vitro fertilization, embryo manipulation, and developmental biology research. Research has optimized HMG dose, timing, and mouse strain for maximal oocyte yield and quality, and examined how superovulation affects epigenetic markers in resulting embryos.
HMG provides a biologically active mixed FSH/LH preparation for studying FSHR and LHR receptor pharmacology in cell culture systems. Recombinant FSH and LH are used for receptor-selective studies; HMG is used when physiological co-stimulation is the research requirement. Research has examined how combined FSHR and LHR signaling in granulosa and luteal cells differs from selective receptor activation in terms of cAMP kinetics, steroidogenesis gene expression, and anti-apoptotic signaling.
HMG is a urinary mixture of FSH and LH with natural glycosylation patterns. Recombinant FSH is a pure single-protein preparation without LH activity. In research, recombinant FSH is preferred for FSHR-selective studies; HMG is used when combined FSH+LH stimulation is needed — for superovulation protocols or when physiological gonadotropin co-stimulation is the experimental requirement.
HMG is standardized by biological activity assay (Steelman-Pohley assay for FSH, ovarian weight gain assay for LH) to defined IU (international units) per vial. This activity-based standardization accounts for glycosylation variation between preparations and is the standard for gonadotropin research reagents.
HMG is supplied with standardized gonadotropin activity verified by activity assay. Specific IU/vial is stated in the Certificate of Analysis accompanying each batch. Contact us via the Request page for current inventory specifications.
HMG should be stored at 2-8°C in dry conditions for short-term storage, or at −20°C for long-term storage. Reconstituted solutions should be used within 24 hours. Glycoprotein hormones are susceptible to denaturation at elevated temperatures.
For laboratory research use only. Not for human or veterinary use. PeptidesFromChina.co is a B2B wholesale supplier operating under strict research-use-only terms. All products are sold exclusively for in vitro and preclinical research purposes.