Hexarelin is a growth peptides research compound currently in stock directly from a verified Chinese manufacturer. Every batch is HPLC-verified and shipped with a Certificate of Analysis (COA). Sourcing is direct — no intermediaries. Minimum order value is $600 USD. International shipping available.
Hexarelin (Examorelin) is a synthetic hexapeptide GH secretagogue and GHS-R1a agonist, structurally related to GHRP-6 but with a 2-methyl-tryptophan (α-methyltryptophan) at position 2 — a modification associated with the highest reported GH-releasing potency among the hexapeptide GHRP family. Beyond its pituitary effects, hexarelin is notable in research for cardiovascular activity mediated via CD36 (scavenger receptor B) and a distinct GHS-R1a-independent pathway, making it a pharmacologically complex research tool that spans GH axis and cardiac biology.
Preclinical studies have documented hexarelin's robust GH stimulation in rodent and primate models, generally exceeding the GH release amplitude achieved by GHRP-6 or GHRP-2 at equivalent doses. A separate line of research has examined hexarelin's cardioprotective properties in ischemia-reperfusion injury models — an area of interest because the observed cardiac effects appear to persist even in somatostatin-suppressed or hypophysectomized animals, implicating a GH-independent receptor mechanism (CD36) in cardiac signaling.
PeptidesFromChina.co supplies hexarelin as a lyophilized powder at 99%+ purity, verified by HPLC and Mass Spectrometry. Certificate of Analysis accompanies every batch. All products are for laboratory research use only and are not for human consumption.
| Chemical Class | Synthetic hexapeptide (GH secretagogue) |
|---|---|
| Synonyms | Examorelin, GHRP (hexapeptide), EP-23905, MF-6003 |
| Sequence | His-D-2-MeTrp-Ala-Trp-D-Phe-Lys-NH₂ |
| Amino Acids | 6 |
| Molecular Formula | C₄₇H₅₈N₁₂O₆ |
| Molecular Weight | 887.1 Da |
| CAS Number | 140703-51-1 |
| PubChem CID | 6918572 |
| Receptor Targets | GHS-R1a (primary), CD36 scavenger receptor (GH-independent cardiac pathway) |
| Research Areas | GH axis pharmacology, cardiac protection, ischemia-reperfusion research, dual-receptor pharmacology |
| Form | Lyophilized powder |
| Storage | −20°C long-term; 2-8°C aqueous (use within 2 weeks) |
| Name | Strength | Pack Size | Purity | Availability | Price (USD) |
|---|---|---|---|---|---|
| Hexarelin | 5 mg | 10 vials | ≥98% | In Stock | $94.00 |
Testing method: HPLC / LC-MS. Every batch is tested before shipment. Purity ≥99% confirmed per batch.
Certificate of Analysis (COA) is included with every order. Documentation covers purity, molecular weight, and batch identification.
Hexarelin is among the most potent GHS-R1a agonists in the hexapeptide GHRP family, producing high-amplitude GH pulses in rodent and primate models. Structure-activity research has examined how the 2-methyltryptophan modification affects receptor binding affinity, selectivity, and GH release amplitude compared to GHRP-6 (tryptophan at position 2) and GHRP-2 (2-naphthylalanine). Hexarelin's potency profile makes it a useful upper-end reference in GHS-R1a pharmacological studies.
A distinct research area for hexarelin involves cardioprotective activity that persists in hypophysectomized animals and in the presence of somatostatin — conditions that abolish pituitary GH release. This GH-independent activity has been traced to CD36, a scavenger receptor expressed in cardiac tissue. Studies in ischemia-reperfusion models have examined hexarelin's effects on cardiomyocyte survival, infarct size reduction, and contractile recovery through this alternative receptor pathway.
Hexarelin's dual receptor engagement — GHS-R1a in the pituitary and CD36 in cardiac and vascular tissue — has generated research interest in separating its GH-dependent from GH-independent biological effects. Studies using hypophysectomy, GH antibody neutralization, and CD36-knockout models have been used to parse these distinct pharmacological contributions, making hexarelin a valuable tool for studying GH secretagogue biology beyond the pituitary.
Hexarelin uses a 2-methyltryptophan at position 2, giving it the highest GH-releasing potency in the hexapeptide GHRP family. Unlike GHRP-6 or GHRP-2, hexarelin also engages the CD36 receptor in cardiac tissue — a GH-independent pathway relevant to cardiac research. It is the most pharmacologically complex of the three.
Yes — hexarelin's cardiac effects via CD36 are documented in hypophysectomized rodent models where GH secretion is eliminated. This allows researchers to study CD36-mediated cardioprotection independently of the GH axis, using hexarelin as a selective CD36 pharmacological probe in cardiac research contexts.
Hexarelin is synthesized to 99%+ purity, verified by HPLC and Mass Spectrometry. Certificate of Analysis from the originating facility is included with every batch.
Store lyophilized hexarelin at −20°C, protected from moisture and light. Aqueous solutions should be kept at 2-8°C and used within 2 weeks.
For laboratory research use only. Not for human or veterinary use. PeptidesFromChina.co is a B2B wholesale supplier operating under strict research-use-only terms. All products are sold exclusively for in vitro and preclinical research purposes.