DSIP is a metabolic & longevity research compound currently in stock directly from a verified Chinese manufacturer. Every batch is HPLC-verified and shipped with a Certificate of Analysis (COA). Sourcing is direct — no intermediaries. Minimum order value is $600 USD. International shipping available.
DSIP (Delta Sleep-Inducing Peptide) is a naturally occurring neuropeptide first isolated from rabbit cerebral venous blood during slow-wave sleep in 1977. The 9-amino acid sequence — Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu — exhibits amphiphilic properties that allow it to cross the blood-brain barrier, an unusual characteristic for peptides of its size. Research interest in DSIP spans neuroendocrine signaling, stress response modulation, and the neurochemistry of sleep-wake cycles.
Preclinical studies in rodent models have examined DSIP in the context of EEG slow-wave activity, hypothalamic-pituitary axis interactions (particularly corticotropin and LH release), and stress-induced behavioral endpoints. Research has also explored DSIP's antioxidant properties — an unexpected finding for a neuropeptide — and its potential role as a modulator of cellular stress responses under conditions of oxidative challenge. The compound's amphiphilicity and CNS penetration make it a valuable pharmacological probe in neuroscience research.
PeptidesFromChina.co supplies DSIP as a lyophilized powder at 99%+ purity, verified by HPLC and Mass Spectrometry. Certificate of Analysis accompanies every batch. All products are for laboratory research use only and are not for human consumption.
| Chemical Class | Naturally occurring neuropeptide |
|---|---|
| Synonyms | Delta Sleep-Inducing Peptide, DSIP, Deltaran |
| Sequence | Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu |
| Amino Acids | 9 |
| Molecular Formula | C₃₅H₄₈N₈O₁₅ |
| Molecular Weight | 848.9 Da |
| CAS Number | 62568-57-4 |
| Research Areas | Sleep neuroscience, neuroendocrine regulation, stress response, antioxidant signaling, CNS pharmacology |
| Form | Lyophilized powder |
| Storage | −20°C long-term; 2-8°C aqueous (use within 2 weeks) |
| Name | Strength | Pack Size | Purity | Availability | Price (USD) |
|---|---|---|---|---|---|
| DSIP | 5 mg | 10 vials | ≥98% | In Stock | $50.00 |
| DSIP | 10 mg | 10 vials | ≥98% | In Stock | $94.00 |
Testing method: HPLC / LC-MS. Every batch is tested before shipment. Purity ≥99% confirmed per batch.
Certificate of Analysis (COA) is included with every order. Documentation covers purity, molecular weight, and batch identification.
DSIP was originally characterized by its ability to induce slow-wave sleep in rabbits following cerebral perfusion. Subsequent rodent EEG studies have examined its effects on sleep architecture — specifically delta wave activity, sleep onset latency, and REM/NREM ratios. Research interest lies in understanding whether DSIP acts as an endogenous sleep-promoting signal and how its central concentrations correlate with sleep stage transitions.
Research has examined DSIP's effects on hypothalamic-pituitary hormone release, including corticotropin (ACTH/cortisol axis) and LH (luteinizing hormone). Studies in stressed rodent models suggest DSIP may modulate the stress-activated HPA axis response. The mechanism is not fully characterized but appears to involve hypothalamic receptor interactions distinct from the primary sleep-induction pathway.
An unexpected area of DSIP research involves its apparent antioxidant properties in cell culture and in vivo models. Studies have measured reactive oxygen species (ROS) reduction and mitochondrial protection markers following DSIP exposure in stress models. This cytoprotective activity is mechanistically distinct from its neuroendocrine effects and represents a secondary research interest in oxidative stress biology.
DSIP (Delta Sleep-Inducing Peptide) is a 9-amino acid neuropeptide studied primarily for its role in slow-wave sleep induction, neuroendocrine modulation (HPA and LH axes), and — more recently — antioxidant and cytoprotective properties. It is used as a research tool in sleep neuroscience and stress response biology.
Yes — DSIP is one of the few small peptides documented to cross the blood-brain barrier in preclinical models, likely due to its amphiphilic structure. This CNS penetration is a key reason for its research interest in neurological applications.
DSIP is synthesized to 99%+ purity, verified by HPLC and Mass Spectrometry. Certificate of Analysis from the originating facility is included with every batch.
Lyophilized DSIP should be stored at −20°C, protected from light and moisture. Aqueous solutions should be kept at 2-8°C and used within 2 weeks.
For laboratory research use only. Not for human or veterinary use. PeptidesFromChina.co is a B2B wholesale supplier operating under strict research-use-only terms. All products are sold exclusively for in vitro and preclinical research purposes.