AOD-9604 is a weight management research compound currently in stock directly from a verified Chinese manufacturer. Every batch is HPLC-verified and shipped with a Certificate of Analysis (COA). Sourcing is direct — no intermediaries. Minimum order value is $600 USD. International shipping available.
AOD-9604 is a synthetic 16-amino acid peptide fragment corresponding to residues 176-191 of human growth hormone (hGH), modified with an additional tyrosine at the N-terminus. It was originally developed as a research compound to investigate whether the lipolytic properties attributed to the C-terminal region of hGH could be isolated from the growth-promoting and insulin-desensitizing effects associated with the full-length hormone. This separation of function is the central mechanistic research interest of AOD-9604.
Preclinical studies in rodent models of diet-induced obesity have examined AOD-9604's effects on adipose tissue lipolysis and fat oxidation. Research suggests it may interact with beta-3 adrenergic receptors — a pathway distinct from the IGF-1 axis through which native hGH exerts its growth-promoting effects. This receptor-level differentiation supports the hypothesis that AOD-9604 produces metabolic activity without the anabolic, hyperglycemic, or IGF-1-mediated effects of full-length growth hormone, though the mechanistic picture remains under investigation.
PeptidesFromChina.co supplies AOD-9604 as a lyophilized powder in sealed vials at 99%+ purity, verified by HPLC and Mass Spectrometry. Certificate of Analysis accompanies every batch. All products are intended for laboratory research use only and are not for human consumption.
| Chemical Class | Synthetic hGH fragment (modified C-terminal region) |
|---|---|
| Synonyms | HGH Fragment 176-191 (Tyr variant), AOD9604 |
| Sequence | Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe (disulfide bond Cys7-Cys15) |
| Amino Acids | 16 |
| Molecular Formula | C₇₈H₁₂₃N₂₃O₂₃S₂ |
| Molecular Weight | 1815.1 Da |
| CAS Number | 221231-10-3 |
| Research Areas | Adipose metabolism, lipolysis, beta-3 adrenergic signaling, hGH fragment pharmacology |
| Form | Lyophilized powder |
| Storage | −20°C long-term; 2-8°C aqueous (short-term) |
| Name | Strength | Pack Size | Purity | Availability | Price (USD) |
|---|---|---|---|---|---|
| AOD-9604 | 2 mg | 10 vials | ≥98% | In Stock | $60.00 |
| AOD-9604 | 5 mg | 10 vials | ≥98% | In Stock | $107.00 |
| AOD-9604 | 10 mg | 10 vials | ≥98% | In Stock | $200.00 |
Testing method: HPLC / LC-MS. Every batch is tested before shipment. Purity ≥99% confirmed per batch.
Certificate of Analysis (COA) is included with every order. Documentation covers purity, molecular weight, and batch identification.
The primary research focus for AOD-9604 is adipose tissue lipolysis. Rodent studies have examined its effects on fat cell breakdown and fatty acid release in visceral and subcutaneous fat depots. The proposed mechanism involves beta-3 adrenergic receptor interaction, which differs from the GH receptor-mediated pathway responsible for hGH's full anabolic effects — a mechanistic distinction central to AOD-9604's research value.
A key area of investigation is whether AOD-9604 produces its metabolic effects without engaging the IGF-1 axis — the growth-promoting pathway activated by full-length hGH via the GH receptor. Studies have examined IGF-1 levels in rodent models following AOD-9604 administration, with research interest in confirming functional separation from growth hormone receptor signaling.
AOD-9604 serves as a useful research tool for studying structure-function relationships within the hGH molecule. By isolating a specific C-terminal region, researchers can examine which biological activities reside in distinct domains of the full-length protein — contributing to broader understanding of growth hormone molecular pharmacology.
AOD-9604 and HGH Fragment 176-191 are closely related — AOD-9604 includes an additional N-terminal tyrosine residue (Tyr at position 176, rather than starting at Leu). This modification affects solubility and stability. We supply both variants — check the catalog for available forms.
Preclinical studies suggest AOD-9604 does not significantly elevate IGF-1 levels in rodent models, which distinguishes it from full-length hGH. This mechanistic separation is a primary research interest — though findings vary by study design and are not yet translated to human applications.
AOD-9604 is synthesized to 99%+ purity, verified by HPLC and Mass Spectrometry. Certificate of Analysis from the originating facility is included with every batch.
Lyophilized AOD-9604 should be stored at −20°C, away from light and moisture. Aqueous solutions should be kept at 2-8°C and used within 3-4 weeks.
For laboratory research use only. Not for human or veterinary use. PeptidesFromChina.co is a B2B wholesale supplier operating under strict research-use-only terms. All products are sold exclusively for in vitro and preclinical research purposes.