Adipotide is a weight management research compound currently in stock directly from a verified Chinese manufacturer. Every batch is tested by the manufacturer for purity and concentration as part of routine quality control. Sourcing is direct — no intermediaries. Minimum order value is $600 USD. International shipping available.
Adipotide (CKGGRAKDC-GG-D(KLAKLAK)₂) is a synthetic proapoptotic peptidomimetic designed with a bifunctional architecture: a targeting domain (CKGGRAKDC) that homes to prohibitin on the vascular endothelium of white adipose tissue, linked via a GG spacer to a killing domain (D(KLAKLAK)₂) that disrupts mitochondrial membranes and induces apoptosis in targeted cells. The rationale behind adipotide is selective destruction of the vasculature feeding white adipose tissue deposits — reducing blood supply and inducing adipocyte death through ischemia, without systemic effects on other tissues that do not express the target receptor.
Preclinical research in non-human primates (rhesus macaques) and rodent obesity models has examined adipotide's effects on body weight, fat mass distribution, and metabolic parameters. The prohibitin-targeting component was identified through phage display peptide library screening of white adipose vasculature, and adipotide represents the lead compound from that work. Research findings in non-human primates documented significant fat mass reduction, particularly in visceral adipose depots, with effects on renal tubular cells as the primary documented off-target toxicity — a research finding of significant mechanistic interest for understanding prohibitin expression in kidney versus adipose tissue.
PeptidesFromChina.co supplies Adipotide as a lyophilized powder at 99%+ purity, verified by HPLC and Mass Spectrometry. Every batch is tested by the manufacturer for purity and concentration as part of routine quality control. All products are for laboratory research use only and are not for human consumption.
| Chemical Class | Bifunctional proapoptotic peptidomimetic (targeting + killing domains) |
|---|---|
| Synonyms | CKGGRAKDC-GG-D(KLAKLAK)₂, fat-homing proapoptotic peptide |
| Architecture | CKGGRAKDC (prohibitin-targeting) — GG spacer — D(KLAKLAK)₂ (mitochondrial disruption) |
| Molecular Weight | ~2500 Da |
| Primary Target | Prohibitin on white adipose vasculature endothelium |
| Research Areas | Adipose vascular biology, selective tissue targeting, proapoptotic peptide pharmacology, obesity models |
| Form | Lyophilized powder |
| Storage | −20°C long-term; 2-8°C aqueous (use promptly) |
| Sequence | CKGGRAKDC-GG-D(KLAKLAK)₂ |
| CAS Number | Available on request |
| Molecular Formula | N/A — bifunctional peptidomimetic |
| Name | Strength | Pack Size | Purity | Availability | Price (USD) |
|---|---|---|---|---|---|
| Adipotide | 2 mg | 10 vials | ≥98% | In Stock | $88.00 |
| Adipotide | 5 mg | 10 vials | ≥98% | In Stock | $194.00 |
Testing method: HPLC / LC-MS (["Water Content","LC-MS","HPLC"]). Every batch is tested before shipment. Purity ≥99% confirmed per batch.
Available documentation: Manufacturer COA. Where provided, these documents reflect the manufacturer's batch testing for this compound.
Prohibitin is expressed on the luminal surface of white adipose vascular endothelium, providing a target for the CKGGRAKDC homing domain of adipotide. Research has characterized prohibitin's role in adipose vascular biology, its expression across different fat depots (visceral versus subcutaneous), and how prohibitin surface availability changes with obesity state. Adipotide serves as a pharmacological probe for studying prohibitin function and vascular targeting in adipose tissue.
The D(KLAKLAK)₂ killing domain is an amphipathic, membrane-disrupting peptide that preferentially attacks mitochondrial inner membranes — a strategy originally developed for targeted cell killing in cancer research. In adipotide, this domain is redirected to adipose vascular endothelium via the CKGGRAKDC homing sequence. Research has examined the selectivity of this mitochondrial disruption mechanism in adipose versus non-adipose endothelial cells, and the dose-response relationship between mitochondrial damage and apoptotic cell death in vitro.
When adipose vasculature is targeted and apoptosis induced in endothelial cells, the downstream effect is reduced blood supply to adipose tissue — producing ischemia-driven adipocyte death. Research in rodent obesity models has examined the temporal sequence from endothelial apoptosis to adipocyte death, the histological characteristics of adipotide-treated adipose tissue (TUNEL staining, CD31 vascular density), and the metabolic consequences of adipose depot reduction.
Selectivity is determined by the CKGGRAKDC homing domain, which targets prohibitin expressed on white adipose vascular endothelium. Other vascular beds with lower prohibitin surface expression receive less compound. This targeting selectivity is the primary mechanism of tissue specificity — though off-target effects (notably renal tubular cells, which also express prohibitin) have been documented in preclinical research and represent a key area of mechanistic investigation.
The renal toxicity observed in non-human primate studies — tubular cell apoptosis due to prohibitin expression in kidney — represents a significant off-target effect that limits therapeutic translation. This finding is itself research-valuable: it defines the prohibitin expression pattern in kidney versus adipose tissue and establishes the selectivity requirements for next-generation targeting sequences. Adipotide is used as the reference proapoptotic adipose-targeting peptide in research developing more selective analogues.
Adipotide is synthesized to 99%+ purity, verified by HPLC and Mass Spectrometry. Every batch is tested by the manufacturer for purity and concentration as part of routine quality control.
Lyophilized adipotide should be stored at −20°C. Reconstituted solutions should be used promptly. The bifunctional peptide contains a D(KLAKLAK)₂ domain with D-amino acids, providing good proteolytic stability.
For laboratory research use only. Not for human or veterinary use. PeptidesFromChina.co is a B2B wholesale supplier operating under strict research-use-only terms. All products are sold exclusively for in vitro and preclinical research purposes.