5-Amino-1MQ is a weight management research compound currently in stock directly from a verified Chinese manufacturer. Every batch is HPLC-verified and shipped with a Certificate of Analysis (COA). Sourcing is direct — no intermediaries. Minimum order value is $600 USD. International shipping available.
5-Amino-1MQ (5-amino-1-methylquinolinium) is a small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT) — an enzyme that catalyzes the N-methylation of nicotinamide using S-adenosylmethionine (SAM) as a methyl donor, producing 1-methylnicotinamide and S-adenosylhomocysteine. NNMT activity is upregulated in adipose tissue in obesity states, and research has investigated its role in regulating cellular SAM availability, epigenetic methylation capacity, and NAD⁺ precursor flux. By inhibiting NNMT, 5-Amino-1MQ is studied as a tool for examining how nicotinamide methyl metabolism affects adipogenesis, energy expenditure, and metabolic gene expression.
Preclinical research in rodent diet-induced obesity models has examined 5-Amino-1MQ in the context of body composition, adipose tissue metabolism, and metabolic rate. Studies have reported reductions in fat cell size, changes in adipogenic gene expression, and alterations in cellular energy status consistent with NNMT inhibition. The mechanistic hypothesis centers on NNMT inhibition increasing cellular SAM availability for epigenetic methylation reactions — particularly H3K4 methylation — which may alter gene expression programs in adipose tissue. This epigenetic mechanism distinguishes 5-Amino-1MQ from conventional metabolic research compounds.
PeptidesFromChina.co supplies 5-Amino-1MQ as a powder at 99%+ purity, verified by HPLC and NMR. Certificate of Analysis accompanies every batch. All products are for laboratory research use only and are not for human consumption.
| Chemical Class | Methylquinolinium NNMT inhibitor (small molecule) |
|---|---|
| Synonyms | 5-Amino-1-methylquinolinium, 5A1MQ |
| Primary Target | NNMT (Nicotinamide N-methyltransferase) |
| Research Areas | NNMT biology, adipose tissue epigenetics, SAM-dependent methylation, obesity models, NAD⁺ precursor metabolism |
| Form | Powder |
| Storage | −20°C long-term; 2-8°C short-term; protect from light |
| Molecular Formula | C₁₀H₁₀N₂ (free base form) |
| Molecular Weight | 158.2 Da |
| CAS Number | Available on COA |
| Sequence | N/A — small molecule (not a peptide) |
| Name | Strength | Pack Size | Purity | Availability | Price (USD) |
|---|---|---|---|---|---|
| 5-Amino-1MQ | 5 mg | 10 vials | ≥98% | In Stock | $57.00 |
| 5-Amino-1MQ | 10 mg | 10 vials | ≥98% | In Stock | $75.00 |
| 5-Amino-1MQ | 50 mg | 10 vials | ≥98% | In Stock | $110.00 |
Testing method: HPLC / LC-MS. Every batch is tested before shipment. Purity ≥99% confirmed per batch.
Certificate of Analysis (COA) is included with every order. Documentation covers purity, molecular weight, and batch identification.
NNMT is highly expressed in adipose tissue and upregulated in obesity, where it consumes nicotinamide (vitamin B3) and SAM. Research has used 5-Amino-1MQ to examine how NNMT inhibition affects adipocyte differentiation, lipid droplet accumulation, and adipogenic transcription factor activity (PPAR-γ, C/EBPα) in cell culture and rodent models. The working hypothesis is that NNMT inhibition preserves SAM for epigenetic H3K4 methylation events that suppress adipogenic programming.
NNMT consumes SAM — the universal methyl donor for DNA and histone methyltransferases — converting it to S-adenosylhomocysteine while methylating nicotinamide. Research has examined how 5-Amino-1MQ-mediated NNMT inhibition affects cellular SAM/SAH ratios, global histone methylation patterns, and gene expression programs regulated by SAM-dependent methylation. This positions 5-Amino-1MQ as a tool for studying the interface between one-carbon metabolism and epigenetic regulation.
By inhibiting NNMT, 5-Amino-1MQ preserves nicotinamide for NAD⁺ biosynthesis via the NAMPT pathway rather than diverting it to 1-methylnicotinamide. Research has examined whether this shift in nicotinamide flux increases cellular NAD⁺ levels and downstream sirtuin (SIRT1/3) activity — connecting NNMT biology to the growing field of NAD⁺ metabolism and longevity research.
NNMT (Nicotinamide N-methyltransferase) methylates nicotinamide using SAM, consuming two key metabolic substrates: a NAD⁺ precursor (nicotinamide) and the universal methyl donor (SAM). Its upregulation in obese adipose tissue is hypothesized to divert nicotinamide away from NAD⁺ synthesis and reduce SAM availability for epigenetic methylation — making NNMT a research target at the intersection of NAD⁺ metabolism, epigenetics, and metabolic disease.
NMN and NR increase NAD⁺ by providing more precursor substrate. 5-Amino-1MQ increases NAD⁺ precursor availability indirectly by inhibiting NNMT — the enzyme that consumes nicotinamide. Additionally, 5-Amino-1MQ has epigenetic effects via SAM preservation that NMN and NR do not share. They are mechanistically complementary research tools rather than interchangeable.
5-Amino-1MQ is supplied at 99%+ purity, verified by HPLC and NMR. Certificate of Analysis from the manufacturing facility is included with every batch.
Store 5-Amino-1MQ at −20°C, protected from light and moisture. The compound is stable as a dry powder. Aqueous solutions should be prepared fresh and kept at 2-8°C for short-term use.
For laboratory research use only. Not for human or veterinary use. PeptidesFromChina.co is a B2B wholesale supplier operating under strict research-use-only terms. All products are sold exclusively for in vitro and preclinical research purposes.