Gonadorelin Acetate is a hormonal regulation research compound currently in stock directly from a verified Chinese manufacturer. Every batch is HPLC-verified and shipped with a Certificate of Analysis (COA). Sourcing is direct — no intermediaries. Minimum order value is $600 USD. International shipping available.
Gonadorelin acetate is the synthetic form of GnRH (gonadotropin-releasing hormone), the endogenous hypothalamic decapeptide that controls the reproductive axis by stimulating pituitary release of LH (luteinizing hormone) and FSH (follicle-stimulating hormone). The native sequence — pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH₂ — is highly conserved across vertebrates, and gonadorelin acetate reproduces this sequence in synthetic form with acetic acid as the counterion. As the endogenous GnRH agonist (unmodified), gonadorelin has a very short plasma half-life (~2-8 minutes), which is clinically and experimentally exploited: pulsatile administration mimics endogenous GnRH physiology, while continuous infusion produces pituitary GnRH receptor desensitization and LH/FSH suppression.
Research applications for gonadorelin acetate span reproductive endocrinology, pituitary pharmacology, and HPG axis physiology. It is used as the reference GnRH agonist in pituitary cell culture studies of LH and FSH secretion, in GnRH receptor binding assays, and in in vivo rodent models examining pulsatile versus continuous GnRH stimulation on pituitary gonadotroph function. The pulsatile dosing paradigm — reproducing the ~1 pulse/hour physiological pattern — is particularly studied in hypogonadotropic hypogonadism models and in research into the entrainment of the pituitary to hypothalamic GnRH pulse frequency.
PeptidesFromChina.co supplies Gonadorelin acetate as a lyophilized powder at 99%+ purity, verified by HPLC and Mass Spectrometry. Certificate of Analysis accompanies every batch. All products are for laboratory research use only and are not for human consumption.
| Chemical Class | Hypothalamic decapeptide / GnRH agonist (acetate salt) |
|---|---|
| Synonyms | GnRH, Gonadorelin, LHRH, Luteinizing hormone-releasing hormone |
| Sequence | pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH₂ |
| Amino Acids | 10 |
| Molecular Weight | 1182.3 Da |
| CAS Number | 33515-09-2 |
| Receptor Target | GnRHR (gonadotropin-releasing hormone receptor, Gq-coupled) |
| Research Areas | HPG axis physiology, pituitary gonadotroph function, pulsatile neuroendocrine signaling, reproductive endocrinology |
| Form | Lyophilized powder (acetate salt) |
| Storage | −20°C long-term; 2-8°C aqueous (use promptly — short half-life) |
| Molecular Formula | C₅₅H₇₅N₁₇O₁₃ (free base) |
| Name | Strength | Pack Size | Purity | Availability | Price (USD) |
|---|---|---|---|---|---|
| Gonadorelin Acetate | 2 mg | 10 vials | ≥98% | In Stock | $35.00 |
Testing method: HPLC / LC-MS. Every batch is tested before shipment. Purity ≥99% confirmed per batch.
Certificate of Analysis (COA) is included with every order. Documentation covers purity, molecular weight, and batch identification.
Physiological GnRH is released in discrete pulses (~1/hour in adult mammals), and GnRHR responds differentially to pulsatile versus continuous stimulation. Research has used gonadorelin acetate in programmable infusion protocols in rodent models to study how pulse frequency modulates pituitary FSH/LH output ratio, and how pulsatile stimulation maintains versus desensitizes GnRHR. These experiments are foundational in understanding the frequency-encoding capacity of hypothalamic-pituitary signaling.
Gonadorelin acetate serves as the reference GnRHR agonist in receptor binding displacement assays (competing against radiolabeled GnRH analogues) and in functional Gq-IP3-Ca²⁺ signaling studies in pituitary cell cultures. Structure-activity research comparing gonadorelin with synthetic GnRH analogues (buserelin, leuprolide) that have modified position 6 or 10 has defined the GnRHR pharmacophore and the structural requirements for receptor activation versus sustained agonism.
In rodent models of hypogonadotropic hypogonadism (caused by GnRH neuron ablation, kisspeptin deficiency, or hypothalamic lesions), gonadorelin administered in a pulsatile fashion has been studied for its ability to restore gonadotropin secretion and gonadal function. This research directly models the use of pulsatile GnRH in the treatment of idiopathic hypogonadotropic hypogonadism and contributes to understanding of the minimal GnRH signal required to maintain reproductive axis function.
Gonadorelin is the unmodified native GnRH sequence with a short ~2-8 minute half-life. Long-acting GnRH analogues (leuprolide, buserelin, histrelin) have modifications at positions 6 and/or 10 that dramatically extend half-life and increase receptor affinity. Paradoxically, sustained GnRH agonist exposure causes receptor desensitization and LH/FSH suppression — the opposite of pulsatile gonadorelin, which stimulates gonadotropin release. This pharmacodynamic difference is fundamental to GnRH research.
The pituitary responds to GnRH pulses with maintained FSH and LH secretion, but desensitizes and suppresses gonadotropin output under continuous GnRH stimulation. This frequency-encoding capacity is a unique feature of GnRHR signaling studied as a model for how the pituitary decodes neuroendocrine pulse information. Research protocols using gonadorelin in pulse generators or intermittent injection schedules are designed specifically to exploit or study this distinction.
Gonadorelin acetate is synthesized to 99%+ purity, verified by HPLC and Mass Spectrometry. Certificate of Analysis from the manufacturing facility is included with every batch.
Lyophilized gonadorelin acetate should be stored at −20°C. Aqueous solutions should be prepared fresh and used promptly due to the short intrinsic half-life. The pyroglutamate N-terminus confers some stability against aminopeptidase degradation.
For laboratory research use only. Not for human or veterinary use. PeptidesFromChina.co is a B2B wholesale supplier operating under strict research-use-only terms. All products are sold exclusively for in vitro and preclinical research purposes.