Vitamin B12 (Cyanocobalamin) is a metabolic & longevity research compound currently in stock directly from a verified Chinese manufacturer. Every batch is HPLC-verified and shipped with a Certificate of Analysis (COA). Sourcing is direct — no intermediaries. Minimum order value is $600 USD. International shipping available.
Cyanocobalamin is the synthetic, most stable form of vitamin B12 — a water-soluble organometallic coenzyme with a cobalt center coordinated in a corrin ring. Cyanocobalamin is distinguished from other B12 vitamers (methylcobalamin, adenosylcobalamin, hydroxocobalamin) by the cyano ligand bound to cobalt; in the body, cyanocobalamin is converted to the active coenzyme forms methylcobalamin and 5-deoxyadenosylcobalamin. These active forms serve as cofactors for two critical enzymatic reactions: methionine synthase (methylcobalamin — remethylation of homocysteine to methionine, essential for SAM production and one-carbon metabolism) and methylmalonyl-CoA mutase (adenosylcobalamin — isomerization of methylmalonyl-CoA to succinyl-CoA, essential for amino acid and odd-chain fatty acid catabolism).
Research interest in cyanocobalamin and vitamin B12 spans one-carbon metabolism, neurological function, and methylation research. B12 deficiency produces two distinct biochemical defects: elevated homocysteine (methylation pathway blockade, measurable as hyperhomocysteinemia) and elevated methylmalonic acid (MMA — odd-chain fatty acid catabolism blockade, measurable by urine/plasma MMA). These biochemical markers are used in research to assess B12 adequacy and to study the downstream effects of B12 deficiency on DNA methylation, neurological integrity, and cardiovascular risk markers. Cyanocobalamin injection preparations deliver B12 systemically without dependence on intrinsic factor-mediated intestinal absorption.
PeptidesFromChina.co supplies Cyanocobalamin (Vitamin B12) as a lyophilized powder or injectable formulation at verified concentration. Certificate of Analysis accompanies every batch. All products are for laboratory research use only and are not for human consumption.
| Chemical Class | Cobalamin (vitamin B12 vitamer, synthetic stable form) |
|---|---|
| Synonyms | Cyanocobalamin, Vitamin B12, Cobalamin (cyano form) |
| Molecular Formula | C₆₃H₈₈CoN₁₄O₁₄P |
| Molecular Weight | 1355.4 Da |
| CAS Number | 68-19-9 |
| PubChem CID | 5479203 |
| Active Coenzyme Forms | Methylcobalamin (methionine synthase), Adenosylcobalamin (methylmalonyl-CoA mutase) |
| Research Areas | One-carbon metabolism, homocysteine biology, methylation research, neurological function, B12 deficiency models |
| Form | Lyophilized powder / injectable formulation |
| Storage | 2-8°C; protect from light (light-sensitive); aqueous solutions stable at 2-8°C short-term |
| Sequence | N/A — corrinoid compound (not a peptide) |
| Name | Strength | Pack Size | Purity | Availability | Price (USD) |
|---|---|---|---|---|---|
| Vitamin B12 (Cyanocobalamin) | 10 mg | 10 vials | ≥98% | In Stock | $25.00 |
Testing method: HPLC / LC-MS. Every batch is tested before shipment. Purity ≥99% confirmed per batch.
Certificate of Analysis (COA) is included with every order. Documentation covers purity, molecular weight, and batch identification.
Methylcobalamin is the cofactor for methionine synthase — the enzyme that regenerates methionine from homocysteine using 5-methyltetrahydrofolate as the methyl donor. This reaction is the central node of one-carbon metabolism: it connects the folate cycle (methylenetetrahydrofolate reductase, MTHFR) to the methionine cycle (SAM production, SAM-dependent methylation). Research using B12-deficient cell cultures and animal models defines how B12 availability affects SAM/SAH ratios, global DNA methylation, and gene expression in metabolic and neurological research contexts.
B12 deficiency produces subacute combined degeneration of the spinal cord — a neurological syndrome reflecting the role of methylcobalamin in myelin maintenance. Research has examined the mechanistic link between B12-dependent methylation reactions and myelin basic protein gene expression, and between elevated methylmalonic acid (from adenosylcobalamin deficiency) and neuronal mitochondrial function. B12-deficient rodent models are used to study the neurostructural consequences of methylation cycle blockade.
Hyperhomocysteinemia — elevated plasma homocysteine — is an established marker of B12/folate deficiency and a cardiovascular risk factor in epidemiological research. Studies have examined how homocysteine affects endothelial function, platelet activation, oxidative stress (homocysteine auto-oxidizes to generate superoxide), and smooth muscle cell proliferation. B12 treatment as a homocysteine-lowering intervention in these models provides mechanistic insight into the relationship between one-carbon metabolism and vascular biology.
Cyanocobalamin is the synthetic stable storage form; methylcobalamin is the bioactive coenzyme form directly used by methionine synthase. Cyanocobalamin must be converted in the body to methylcobalamin and adenosylcobalamin. Methylcobalamin is preferred in research where direct coenzyme activity without conversion steps is required, or for CNS studies (as methylcobalamin crosses the blood-brain barrier more readily). Cyanocobalamin is preferred for stability and storage.
Homocysteine (elevated due to methionine synthase blockade — methylcobalamin deficiency) and methylmalonic acid (MMA, elevated due to methylmalonyl-CoA mutase blockade — adenosylcobalamin deficiency). Both markers are used to assess B12 adequacy in deficiency models, with MMA being more specific for B12 deficiency than homocysteine (which is also elevated in folate and B6 deficiency).
Cyanocobalamin is supplied at 99%+ purity, verified by HPLC. Certificate of Analysis from the manufacturing facility is included with every batch.
The cobalt-corrin ring and cyano ligand in cyanocobalamin are photosensitive — UV and visible light cause degradation of the molecule, reducing its activity. Aqueous solutions exposed to light can lose significant activity within hours. Store in amber vials and minimize light exposure during preparation.
For laboratory research use only. Not for human or veterinary use. PeptidesFromChina.co is a B2B wholesale supplier operating under strict research-use-only terms. All products are sold exclusively for in vitro and preclinical research purposes.