VIP is a healing & repair research compound currently in stock directly from a verified Chinese manufacturer. Every batch is HPLC-verified and shipped with a Certificate of Analysis (COA). Sourcing is direct — no intermediaries. Minimum order value is $600 USD. International shipping available.
VIP (Vasoactive Intestinal Peptide) is a 28-amino acid neuropeptide and member of the glucagon/secretin superfamily, widely expressed throughout the central and peripheral nervous systems as well as in gut mucosa and immune tissues. Originally isolated from porcine intestine based on its potent vasodilatory activity, VIP has since been recognized as a pleiotropic regulatory peptide with roles in neurotransmission, smooth muscle relaxation, exocrine secretion, circadian rhythm regulation, and immunomodulation. It acts primarily via VPAC1 and VPAC2 G protein-coupled receptors (coupled to Gs-cAMP signaling), with secondary activity at PAC1 receptors shared with the structurally related PACAP.
Research into VIP spans neuroscience, immunology, and endocrinology. In the CNS, VIP is a key co-transmitter in the suprachiasmatic nucleus (SCN) — the master circadian pacemaker — where it coordinates circadian gene expression across neuronal populations. In the immune system, VIP acts as an anti-inflammatory mediator, suppressing macrophage activation, reducing pro-inflammatory cytokine production (TNF-α, IL-6, IL-12), and promoting regulatory T cell (Treg) differentiation — a profile of research interest in inflammatory and autoimmune disease models.
PeptidesFromChina.co supplies VIP as a lyophilized powder at 99%+ purity, verified by HPLC and Mass Spectrometry. Certificate of Analysis accompanies every batch. All products are for laboratory research use only and are not for human consumption.
| Chemical Class | Neuropeptide (glucagon/secretin superfamily) |
|---|---|
| Synonyms | Vasoactive Intestinal Peptide, VIP-28 |
| Sequence | His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn-NH₂ |
| Amino Acids | 28 |
| Molecular Weight | 3326.8 Da |
| CAS Number | 37221-79-7 |
| Receptor Targets | VPAC1, VPAC2 (primary), PAC1 (secondary) |
| Research Areas | Circadian biology, immunomodulation, neuroinflammation, smooth muscle pharmacology, exocrine signaling |
| Form | Lyophilized powder |
| Storage | −20°C long-term; 2-8°C aqueous (use within 1 week) |
| Molecular Formula | C₁₄₇H₂₃₃N₄₃O₄₃S |
| Name | Strength | Pack Size | Purity | Availability | Price (USD) |
|---|---|---|---|---|---|
| VIP | 10 mg | 10 vials | ≥98% | In Stock | $194.00 |
Testing method: HPLC / LC-MS. Every batch is tested before shipment. Purity ≥99% confirmed per batch.
Certificate of Analysis (COA) is included with every order. Documentation covers purity, molecular weight, and batch identification.
VIP is a critical neuromodulator in the suprachiasmatic nucleus (SCN), coordinating phase synchronization across circadian oscillator neurons via VPAC2 receptor signaling. Research has examined how VIP-null or VPAC2-null rodents develop desynchronized circadian rhythms at the cellular level, and how exogenous VIP application resets or synchronizes SCN explant cultures. This makes VIP an essential research tool in circadian biology — particularly for studying inter-neuronal communication within the master clock.
VIP exhibits potent anti-inflammatory properties in preclinical models of inflammatory and autoimmune disease. Research has documented VIP suppression of macrophage TNF-α, IL-6, and IL-12 production via cAMP signaling, as well as promotion of Treg differentiation and reduction of Th1/Th17 responses. Rodent models of colitis, arthritis, and experimental autoimmune encephalomyelitis (EAE) have been used to examine VIP's immunomodulatory profile.
VIP's original characterization as a vasodilatory agent drives research into its pharmacology in smooth muscle tissues — including vascular, airway, and GI smooth muscle. VPAC1/VPAC2-mediated cAMP elevation produces smooth muscle relaxation, studied in contexts including pulmonary artery hypertension models, intestinal motility research, and bronchodilation studies. VIP provides a selective endogenous ligand tool for characterizing VPAC receptor function in smooth muscle physiology.
VIP and PACAP share receptors (VPAC1, VPAC2) but differ in potency and receptor selectivity. PACAP also binds PAC1 with high affinity — a receptor VIP activates only weakly. PAC1-specific effects (e.g., PACAP's pituitary hormone stimulation, anti-apoptotic signaling in neurons) are absent with VIP, making VIP the preferred research tool when VPAC-selective effects are required without PAC1 confounds.
VIP is the primary neuromodulator in the suprachiasmatic nucleus (SCN) responsible for synchronizing the circadian clocks of individual neurons into a coherent, population-level rhythm. VIP-knockout rodents show highly desynchronized SCN oscillations. Exogenous VIP applied to SCN explants can reset and synchronize cellular rhythms. This makes VIP an irreplaceable tool in circadian research.
VIP is synthesized to 99%+ purity, verified by HPLC and Mass Spectrometry. Certificate of Analysis from the manufacturing facility is included with every batch.
Lyophilized VIP should be stored at −20°C. Aqueous solutions should be kept at 2-8°C and used within 1 week. VIP is susceptible to adsorption on plastic surfaces — use siliconized tubes for dilute solutions.
For laboratory research use only. Not for human or veterinary use. PeptidesFromChina.co is a B2B wholesale supplier operating under strict research-use-only terms. All products are sold exclusively for in vitro and preclinical research purposes.