PT-141 (Bremelanotide) is a hormonal regulation research compound currently in stock directly from a verified Chinese manufacturer. Every batch is HPLC-verified and shipped with a Certificate of Analysis (COA). Sourcing is direct — no intermediaries. Minimum order value is $600 USD. International shipping available.
PT-141, also known by its INN bremelanotide, is a cyclic heptapeptide melanocortin receptor agonist. It is a metabolite-analogue of Melanotan-2, produced by removal of the C-terminal amide and cyclisation via a lactam bridge, but distinguished by the absence of melanogenic activity at therapeutic doses — a significant pharmacological distinction from MT-2. PT-141 preferentially activates MC3R (melanocortin-3 receptor) and MC4R (melanocortin-4 receptor) over the melanogenesis-linked MC1R, localising its primary preclinical research interest to CNS-mediated arousal pathways and inflammatory modulation. The compound has completed a full clinical development programme for hypoactive sexual desire disorder (HSDD) in premenopausal women, making it one of the few research peptides with a complete translational research record spanning preclinical to Phase III.
Preclinical research on PT-141 spans MC4R-mediated sexual arousal circuits, inflammatory signalling via MC3R in macrophage and endothelial models, and nociception. The MC4R activation pathway in the hypothalamus and limbic system forms the mechanistic basis for PT-141's CNS-mediated effects, distinct from vasodilatory mechanisms studied with earlier arousal research compounds. Research into MC3R activation has separately characterised anti-inflammatory cytokine modulation, TNF-α suppression, and endotoxin response models — areas studied independently of the arousal research line.
PeptidesFromChina.co supplies research-grade PT-141 (bremelanotide) as lyophilized powder at ≥98% purity, confirmed by HPLC and mass spectrometry. Batch Certificates of Analysis are available. All product is intended for laboratory research use only and is not for human administration.
| Chemical Class | Cyclic Melanocortin Receptor Agonist |
|---|---|
| INN | Bremelanotide |
| CAS Number | 189691-06-3 |
| Molecular Formula | C₅₀H₆₈N₁₄O₁₀ |
| Molecular Weight | 1025.20 Da |
| Structure | Cyclic heptapeptide (lactam bridge) |
| Receptor Targets | MC3R, MC4R (primary); MC1R (low affinity) |
| Synonyms | PT-141, PL-6983, Bremelanotide |
| Storage | -20°C lyophilized; 4°C reconstituted (up to 14 days) |
| Sequence | Ac-Nle-cyclo(Asp-His-D-Phe-Arg-Trp-Lys)-OH (cyclic heptapeptide) |
| Name | Strength | Pack Size | Purity | Availability | Price (USD) |
|---|---|---|---|---|---|
| PT-141 (Bremelanotide) | 10 mg | 10 vials | ≥98% | In Stock | $75.00 |
Testing method: HPLC / LC-MS. Every batch is tested before shipment. Purity ≥99% confirmed per batch.
Certificate of Analysis (COA) is included with every order. Documentation covers purity, molecular weight, and batch identification.
PT-141's receptor selectivity profile (MC3R > MC4R >> MC1R) makes it a valuable tool for dissecting melanocortin receptor subtype contributions in complex phenotypes. Binding assays and functional cAMP accumulation experiments in MC-receptor transfected cell lines are used to quantify affinity and potency. The compound's cyclic structure confers improved metabolic stability relative to linear melanocortin analogues, extending its utility in ex vivo and short-duration in vivo assays.
MC4R is expressed in paraventricular hypothalamic neurons and limbic circuits involved in motivational and reward behaviour. Preclinical rodent studies demonstrate that intracranial or peripheral PT-141 administration increases sexual behaviour in both male (mount frequency, intromission) and female (lordosis quotient) models in a dose-dependent, MC4R-dependent manner. These studies utilise MC4R knockout models to confirm receptor specificity and distinguish from MT-2's broader melanocortin effects. Human clinical data from the bremelanotide development program provide a rare translational dataset for cross-species comparison.
The MC3R, expressed in macrophages, dendritic cells, and endothelial cells, mediates anti-inflammatory signalling in response to melanocortin agonism. PT-141 and related MC3R agonists suppress LPS-induced TNF-α and IL-6 production in macrophage cell line models (RAW264.7, THP-1). In vivo carrageenan-induced paw oedema and endotoxaemia rodent models demonstrate PT-141's anti-inflammatory activity. This research line is independent of the arousal pathway and is studied in the context of melanocortin system modulation of innate immunity.
Clinical pharmacokinetic data from PT-141 trials documented transient blood pressure elevation (peak ~4 mmHg systolic), attributed to peripheral MC1R/MC3R-mediated vasoconstriction rather than the vasodilatory mechanisms of phosphodiesterase inhibitors. Preclinical rodent and primate haemodynamic studies are used to characterise dose-pressure response relationships and identify the receptor subtypes mediating cardiovascular effects — data relevant to structuring safe research protocols and interpreting cardiovascular safety endpoints in melanocortin research.
Melanotan-2 is a full-agonist at MC1R, MC3R, MC4R, and MC5R — the MC1R activity drives melanogenesis (skin darkening). PT-141 (bremelanotide) is a metabolite-analogue with much lower MC1R affinity, so it does not significantly activate the melanogenesis pathway at research doses. Both share MC4R agonism as a common mechanism in arousal and CNS research models. This selectivity difference is fundamental when designing studies that need to isolate MC4R effects from melanogenic endpoints.
Yes. PT-141 has moderate aqueous solubility. For cell-based assays, it is typically dissolved in DMSO at 10–50 mM stock concentration and diluted into assay buffer to a final DMSO content below 0.1%. For in vivo studies, reconstitution in sterile saline or PBS is used; solubility is sufficient at concentrations used in standard rodent dosing protocols.
PeptidesFromChina.co supplies PT-141 at ≥98% purity as determined by RP-HPLC. Identity is confirmed by ESI-MS. Each batch is accompanied by a Certificate of Analysis from the synthesis facility. For studies requiring higher purity tiers or endotoxin testing, contact us to discuss analytical specifications.
Yes. PT-141 is available through PeptidesFromChina.co on a B2B wholesale basis. Pricing and minimum order quantities are provided on request following account verification. Use the contact form or Request page to initiate an inquiry.
For laboratory research use only. Not for human or veterinary use. PeptidesFromChina.co is a B2B wholesale supplier operating under strict research-use-only terms. All products are sold exclusively for in vitro and preclinical research purposes.