NAD+ is a metabolic & longevity research compound currently in stock directly from a verified Chinese manufacturer. Every batch is HPLC-verified and shipped with a Certificate of Analysis (COA). Sourcing is direct — no intermediaries. Minimum order value is $600 USD. International shipping available.
NAD⁺ (Nicotinamide Adenine Dinucleotide) is a fundamental coenzyme present in all living cells, functioning as an electron carrier in cellular respiration and as a substrate for a family of enzymes — including sirtuins (SIRTs), poly(ADP-ribose) polymerases (PARPs), and CD38 — that regulate DNA repair, gene expression, and metabolic adaptation. Research interest in NAD⁺ has intensified substantially over the past decade, driven by observations that NAD⁺ tissue levels decline with age and metabolic stress in mammalian models, and that restoring these levels produces measurable biological changes in preclinical studies.
Preclinical research using NAD⁺ and its precursors (NMN, NR) in rodent aging and metabolic disease models has examined a broad range of endpoints: mitochondrial function, sirtuin activation (particularly SIRT1 and SIRT3), DNA damage repair capacity via PARP pathway, and inflammatory signaling modulation via CD38 NADase activity. The biological mechanisms are tightly interconnected — sirtuins require NAD⁺ as a co-substrate to deacylate histones and transcription factors, PARP1 consumes NAD⁺ at sites of DNA strand breaks, and CD38 is the primary NAD⁺-consuming enzyme in aging tissue. Understanding how NAD⁺ availability affects these competing consumers is a major research question.
PeptidesFromChina.co supplies NAD⁺ (oxidized form) as a lyophilized powder at 99%+ purity, verified by HPLC. Certificate of Analysis accompanies every batch. All products are for laboratory research use only and are not for human consumption.
| Chemical Class | Pyridine nucleotide coenzyme |
|---|---|
| Synonyms | Nicotinamide Adenine Dinucleotide (oxidized), NAD, DPN, Coenzyme I |
| Molecular Formula | C₂₁H₂₇N₇O₁₄P₂ |
| Molecular Weight | 663.4 Da |
| CAS Number | 53-84-9 |
| PubChem CID | 5892 |
| Research Areas | Cellular energetics, sirtuin biology, DNA repair (PARP), aging models, mitochondrial function, inflammation |
| Form | Lyophilized powder |
| Storage | −20°C long-term; 2-8°C aqueous (use within 24 hours — NAD⁺ is unstable in solution) |
| Sequence | N/A — nucleotide (not a peptide) |
| Name | Strength | Pack Size | Purity | Availability | Price (USD) |
|---|---|---|---|---|---|
| NAD+ | 500 mg | 10 vials | ≥98% | In Stock | $75.00 |
| NAD+ | 1000 mg | 10 vials | ≥98% | In Stock | $125.00 |
Testing method: HPLC / LC-MS (["HPLC","LC-MS","Endotoxins","Water Content","Assay","Impurities","Heavy Metals"]). Every batch is tested before shipment. Purity ≥99% confirmed per batch.
Certificate of Analysis: Manufacturer COA · Simple COA. Documentation is available for every batch sold.
Sirtuins (SIRT1-7) are NAD⁺-dependent deacylases that regulate gene expression, mitochondrial biogenesis, and metabolic adaptation. Research has extensively examined the relationship between NAD⁺ availability and sirtuin activity in aging rodent models — with particular interest in SIRT1 (nuclear metabolic regulation), SIRT3 (mitochondrial protein deacetylation), and SIRT6 (DNA repair and telomere maintenance). NAD⁺ supplementation studies have used these sirtuin endpoints as functional readouts of NAD⁺ restoration.
Poly(ADP-ribose) polymerases (PARPs), particularly PARP1, consume large quantities of NAD⁺ at sites of DNA strand breaks. This enzymatic competition for NAD⁺ between PARPs and sirtuins is a key mechanistic focus in aging research — with the hypothesis that chronic low-level DNA damage in aging tissue leads to PARP overactivation, NAD⁺ depletion, and downstream sirtuin insufficiency. NAD⁺ is used in in vitro PARP assays and as a substrate for studying PARP kinetics.
NAD⁺ is an essential electron acceptor in the mitochondrial electron transport chain. Research has examined how intracellular NAD⁺/NADH ratio affects complex I activity, mitochondrial membrane potential, and ATP production efficiency in aged versus young cell models. Supplementation studies have explored whether NAD⁺ restoration shifts the redox balance and improves mitochondrial respiratory capacity in models of metabolic and age-related dysfunction.
NAD⁺ is the active coenzyme. NMN (nicotinamide mononucleotide) and NR (nicotinamide riboside) are NAD⁺ precursors that are converted intracellularly to NAD⁺. In cell-based and in vivo research, precursors are often used to elevate intracellular NAD⁺ levels because the precursors cross cell membranes more readily. NAD⁺ itself is used directly in cell-free biochemical assays and enzyme kinetics research.
NAD⁺ is susceptible to hydrolysis, particularly at the N-glycosidic bond. Aqueous solutions degrade measurably within hours at room temperature and within days even at 4°C. For research protocols requiring aqueous NAD⁺, prepare fresh solutions immediately before use and keep refrigerated at 2-8°C for no longer than 24 hours.
Our NAD⁺ is supplied at 99%+ purity, verified by HPLC. Certificate of Analysis from the manufacturing facility is included with every batch.
We supply NAD⁺ in the oxidized (NAD⁺) form — the biologically active coenzyme form that serves as an electron acceptor and sirtuin/PARP substrate. The reduced form (NADH) is a different compound available separately.
For laboratory research use only. Not for human or veterinary use. PeptidesFromChina.co is a B2B wholesale supplier operating under strict research-use-only terms. All products are sold exclusively for in vitro and preclinical research purposes.