MGF is a growth peptides research compound currently in stock directly from a verified Chinese manufacturer. Every batch is HPLC-verified and shipped with a Certificate of Analysis (COA). Sourcing is direct — no intermediaries. Minimum order value is $600 USD. International shipping available.
MGF (Mechano Growth Factor) is a splice variant of IGF-1 (Insulin-like Growth Factor 1), specifically the Ec isoform produced in response to mechanical load and tissue damage. Unlike systemic IGF-1 (which circulates from the liver and activates the IGF-1 receptor broadly), MGF is expressed locally in mechanically stressed or injured tissue — particularly skeletal muscle — where it is proposed to activate muscle satellite cells (myosatellite cells) and initiate repair and hypertrophy signaling. The research compound sold as MGF is typically the 24-amino acid C-terminal Ec peptide fragment, which is the domain of IGF-1Ec responsible for satellite cell activation.
Preclinical research in rodent skeletal muscle injury and overload models has examined MGF's role in satellite cell recruitment, proliferation, and differentiation. Proposed mechanisms involve a distinct receptor system from the canonical IGF-1R, operating via a non-IGF-1 receptor pathway — specifically hypothesized to involve CXCR4 or integrin-mediated signaling, though the precise receptor remains under investigation. MGF is also available as a PEGylated form (PEG-MGF) with extended half-life, providing a tool for comparing acute versus sustained Ec peptide signaling in research models.
PeptidesFromChina.co supplies MGF as a lyophilized powder at 99%+ purity, verified by HPLC and Mass Spectrometry. Certificate of Analysis accompanies every batch. Both native MGF and PEG-MGF are available. All products are for laboratory research use only and are not for human consumption.
| Chemical Class | IGF-1 splice variant Ec peptide (C-terminal fragment) |
|---|---|
| Synonyms | Mechano Growth Factor, IGF-1Ec, Ec peptide |
| Amino Acids | 24 (C-terminal Ec domain fragment) |
| Molecular Weight | ~2867 Da |
| CAS Number | 162663-54-9 |
| Research Areas | Skeletal muscle biology, satellite cell activation, mechanotransduction, IGF-1 isoform pharmacology, tissue repair |
| Form | Lyophilized powder |
| Storage | −20°C long-term; 2-8°C aqueous (use within 2 weeks) |
| Molecular Formula | N/A — splice variant C-terminal fragment; see COA |
| Sequence | Available on COA (IGF-1 Ea C-terminal 24-aa fragment) |
| Name | Strength | Pack Size | Purity | Availability | Price (USD) |
|---|---|---|---|---|---|
| MGF | 2 mg | 10 vials | ≥98% | In Stock | $44.00 |
Testing method: HPLC / LC-MS (["HPLC","LC-MS","Water Content"]). Every batch is tested before shipment. Purity ≥99% confirmed per batch.
Certificate of Analysis: Simple COA. Documentation is available for every batch sold.
The primary research interest in MGF is its proposed role in activating skeletal muscle satellite cells (myosatellite cells) — quiescent stem cells that become activated following muscle damage or mechanical overload. Studies in rodent muscle injury models have examined satellite cell proliferation and myotube formation markers following MGF administration. The peptide's local expression pattern (distinct from systemic IGF-1) and proposed non-IGF-1R mechanism make it a unique tool for studying satellite cell biology independently of canonical growth factor receptor pathways.
Research has examined MGF expression patterns in skeletal muscle following eccentric exercise, stretch overload, and myotoxin-induced injury in animal models. Studies tracking Ec peptide production relative to mechanical stimulus magnitude, timing, and recovery have contributed to understanding of how muscle senses and responds to mechanical challenge. MGF serves as a molecular marker of local IGF-1 Ec isoform upregulation in mechanobiology research.
The IGF-1 gene produces multiple splice variants (IGF-1Ea, IGF-1Eb, IGF-1Ec in humans) with distinct tissue expression patterns and proposed functional roles. MGF (IGF-1Ec) research explores how the Ec C-terminal extension confers functional properties absent in the common Ea isoform — particularly local tissue action and satellite cell targeting. Comparative studies using Ea versus Ec peptide fragments in matched models are a key tool in IGF-1 isoform pharmacology.
MGF is the C-terminal Ec peptide of the IGF-1Ec splice variant, proposed to act locally via satellite cell activation through a non-IGF-1R pathway. IGF-1 LR3 is a long-acting IGF-1 analogue that acts through the canonical IGF-1 receptor. They target different signaling pathways and are studied for different aspects of muscle biology.
PEG-MGF is MGF with polyethylene glycol (PEG) attached, extending its half-life from minutes to hours. Native MGF is rapidly degraded in biological media. PEG-MGF allows researchers to study sustained Ec peptide exposure in in vivo models without repeated dosing. Both forms are available through PeptidesFromChina.co.
MGF is synthesized to 99%+ purity, verified by HPLC and Mass Spectrometry. Certificate of Analysis from the manufacturing facility is included with every batch.
Lyophilized MGF should be stored at −20°C. Aqueous solutions should be kept at 2-8°C and used within 2 weeks due to peptide instability in solution.
For laboratory research use only. Not for human or veterinary use. PeptidesFromChina.co is a B2B wholesale supplier operating under strict research-use-only terms. All products are sold exclusively for in vitro and preclinical research purposes.