Acetic Acid 0.6% is a reconstitution research compound currently in stock directly from a verified Chinese manufacturer. Every batch is HPLC-verified and shipped with a Certificate of Analysis (COA). Sourcing is direct — no intermediaries. Minimum order value is $600 USD. International shipping available.
Acetic Acid 0.6% (glacial acetic acid diluted to 0.6% v/v in sterile water) is a specialized reconstitution solvent used primarily for peptides with poor aqueous solubility at neutral pH. Many hydrophobic or aggregation-prone research peptides — particularly GHRH analogues, IGF-1 fragments, and GH-releasing peptides — require an acidic solvent to achieve complete dissolution before subsequent dilution to working concentration. Acetic acid's carboxyl group protonates basic residues (Arg, Lys, His) in the peptide sequence, increasing electrostatic repulsion between peptide molecules and reducing intermolecular aggregation.
The 0.6% concentration (approximately 0.1 M) is a widely used standard in peptide reconstitution research, providing sufficient acidity to dissolve aggregation-prone peptides while remaining dilute enough to minimize acid-induced peptide backbone hydrolysis that occurs at higher acid concentrations. After initial reconstitution in 0.6% acetic acid, the solution is typically diluted 5-10 fold with PBS, BAC water, or saline to achieve target concentration and near-physiological pH for research administration. The final pH of the working solution will depend on the dilution ratio and the buffering capacity of the diluent.
PeptidesFromChina.co supplies Acetic Acid 0.6% as a sterile solution specifically prepared for peptide reconstitution research. Certificate of Analysis accompanies every batch. All products are for laboratory research use only.
| Chemical Class | Dilute organic acid solution (reconstitution solvent) |
|---|---|
| Concentration | 0.6% v/v acetic acid in sterile water |
| pH | ~2.9-3.2 |
| Osmolality | ~100 mOsm/kg (hypotonic) |
| Primary Application | Reconstitution solvent for hydrophobic and aggregation-prone peptides |
| Common Use Cases | GHRH analogues, CJC-1295, IGF-1 LR3, sermorelin, tesamorelin, AOD-9604 |
| Form | Sterile aqueous solution |
| Storage | Room temperature; sealed to prevent evaporative concentration; discard if contaminated |
| CAS Number | N/A — formulated solution (multi-component) |
| Molecular Weight | N/A — formulated solution |
| Molecular Formula | N/A — formulated solution |
| Sequence | N/A — not a peptide |
| Name | Strength | Pack Size | Purity | Availability | Price (USD) |
|---|---|---|---|---|---|
| Acetic Acid 0.6% | 3 ml | 10 vials | Pharmaceutical grade | In Stock | $9.00 |
| Acetic Acid 0.6% | 10 ml | 10 vials | Pharmaceutical grade | In Stock | $12.00 |
Testing method: Sterile / endotoxin tested. Every batch is tested before shipment. Purity ≥99% confirmed per batch.
Certificate of Analysis (COA) is included with every order. Documentation covers purity, molecular weight, and batch identification.
Research in peptide formulation has examined how solvent pH, ionic strength, and composition affect peptide solubility and aggregation state. For aggregation-prone peptides, the relationship between solvent pH and peptide charge state (determined by amino acid pKa values) determines the solubility window. Acetic acid at 0.6% provides a standardized acidic environment that maximizes basic residue protonation and electrostatic repulsion — a primary mechanism for disaggregating hydrophobic peptides before physiological dilution.
Acidic conditions can cause peptide backbone hydrolysis, particularly at Asp-X bonds (D-X fragmentation is acid-catalyzed). Research has characterized the stability of research peptides in 0.6% acetic acid over time — quantifying hydrolysis products by HPLC-MS. The 0.6% concentration is chosen as a practical compromise between dissolution efficiency and peptide chemical stability. Reconstituted solutions in acetic acid should be diluted to working pH promptly and not stored long-term in the acidic vehicle.
When using acetic acid as a reconstitution vehicle in in vivo research, vehicle controls must account for both the acetic acid and the pH of the final injected solution. Studies examining the biological effects of acetic acid vehicle versus PBS vehicle in subcutaneous or intraperitoneal injection models have characterized the local tissue response, demonstrating that dilute acetic acid at final concentrations of 0.05-0.1% (after peptide dilution) is well-tolerated at research injection volumes.
GHRH analogues (CJC-1295 without DAC, sermorelin, tesamorelin), IGF-1 LR3, AOD-9604, and some other hydrophobic or aggregation-prone peptides commonly require acetic acid as the primary reconstitution solvent. After reconstitution, these solutions are diluted with PBS, BAC water, or saline to the working concentration. Check the Certificate of Analysis or contact us for reconstitution guidance specific to each compound.
Standard protocol: (1) Add a small volume of 0.6% acetic acid (typically 0.5-1 mL per mg of peptide) directly to the lyophilized vial. (2) Gently swirl or let sit until fully dissolved — do not vortex. (3) Dilute to working concentration with PBS or BAC water (5-10× dilution brings pH closer to physiological). (4) Divide into aliquots if needed and store at 2-8°C or −20°C.
No. Vinegar (4-8% acetic acid) is not sterile, contains impurities, and is 7-13× more concentrated than 0.6% acetic acid. Using non-sterile, non-pharmaceutical grade solvents introduces contamination risk and incorrect concentration. Only sterile, research-grade 0.6% acetic acid should be used for peptide reconstitution research.
Approximately, yes. 0.6% v/v acetic acid (MW 60.05 g/mol, density 1.005 g/mL) is approximately 0.1 M acetic acid. Both designations are used in peptide reconstitution literature and refer to the same preparation. The 0.6% v/v designation is more practical for volumetric preparation from glacial acetic acid stock.
For laboratory research use only. Not for human or veterinary use. PeptidesFromChina.co is a B2B wholesale supplier operating under strict research-use-only terms. All products are sold exclusively for in vitro and preclinical research purposes.